FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE

描述(申请人提供)：FlyBase是一个长期的信息学资源，提供 拥有主要生物医学遗传学核心遗传和基因组信息的科学界 模型果蝇、黑腹果蝇和果蝇属的其他果蝇。随着持续的爆炸 在主要的全基因组数据集以及科学文献中的信息，模型的作用 生物体数据库在捕获、组织和提取关键信息方面是研究人员必不可少的 用果蝇作为他们的实验系统，用果蝇的研究成果来分组 告知他们对其他系统的研究(包括专注于人类的研究人员)，并 需要如此全面、结构良好的数据源的计算生物学家。FlyBase将 继续整理科学文献，通过专家手册对黑腹果蝇基因组进行注释 通过自动和选择性手动相结合的方式对其他果蝇物种进行整理、注释 方法，并捕获大规模功能基因组数据集。这些不同的数据集将是 整合到FlyBase数据库中，并通过每月定期更新向公众展示 FlyBase网站(http://flybase.org).因此，FlyBase充当了数据的公共门户之一 由NHGRI支持的各种测序和功能基因组学项目和 美国国立卫生研究院的其他研究所，以及其他美国和国际资助机构，以及这项研究 这些文献部分是通过利用这些主要数据集而产生的。加入这三家公司 目前参与此次续签的FlyBase网站是新墨西哥大学的一个小组，该小组 将在FlyBase少数民族行动计划中发挥核心作用。相关性：果蝇的研究 黑素胃肠病继续走在生物通路和网络研究的前沿 细胞和发育生物学、神经生物学和行为生物学的背景知识。它也是世界上 研究变异、复杂性状、种群生物学、生态学和 进化论。果蝇研究的洞察力对人类健康研究直接重要， 这既是因为果蝇和人类的基因组之间的巨大相似性，也是因为 生物过程，允许果蝇研究为人类生物学和疾病研究提供信息，但 还因为黑腹果蝇是研究传播疾病的昆虫媒介的最接近的模型。

DESCRIPTION (provided by applicant): FlyBase is a long-term informatics resource that provides the scientific community with core genetic and genomic information on the major biomedical genetic model, Drosophila melanogaster, and other flies of the genus Drosophila. With the continuing explosion of information in major genome-wide datasets as well as the scientific literature, the role of a model organism database in capturing, organizing and distilling the key information is essential to researchers using Drosophila as their experimental system, to groups using the results of Drosophila research to inform their studies on other systems (including researchers focusing on humans), and to computational biologists who require such comprehensive, well structured data sources. FlyBase will continue to curate the scientific literature, annotate the D. melanogaster genome through expert manual curation, annotate the other Drosophila species by a combination of automatic and selective manual approaches, and capture large-scale functional genomics datasets. These diverse sets of data will be integrated within the FlyBase database and presented to the public through regular monthly updates to the FlyBase website (http://flybase.org). FlyBase thus serves as one of the public portals to data produced by a variety of sequencing and functional genomics projects supported by NHGRI and the other institutes of NIH, as well as by other U.S. and international funding agencies, and to the research literature that is produced in part by taking advantage of these major datasets. Joining the three currently participating FlyBase sites for this renewal is a group at the University of New Mexico which will play a central role in the FlyBase Minority Action Plan. RELEVANCE: Research on Drosophila melanogaster continues to be at the forefront of studies of biological pathways and networks in the context of cell and developmental biology, neurobiology and behavioral biology. It has also been one of the most significant systems for studying variation, complex traits, population biology, ecology and evolution. The insights from Drosophila research are of direct importance to human health research, both because of the tremendous similarities between the Drosophila and human gene sets and biological processes, allowing Drosophila research to inform studies of human biology and disease, but also because Drosophila melanogaster is the closest model for research on insect vectors of disease.