FLYBASE: A DROSOPHILA GENOMIC & GENETIC DATABASE

描述(申请人提供)：FlyBase是一个关于主要遗传模式生物、果蝇、黑腹果蝇和果蝇科相关生物的核心遗传和基因组信息的数据库。D.在理解基因及其编码产物之间错综复杂的相互作用以驱动复杂的生物过程(如胚胎身体计划的形成或神经系统的连接)方面，D.黑腹蛇一直是、并将继续是先驱生物。有证据表明，这种复杂的生物事件有一个古老的起源，早于昆虫和脊椎动物谱系的分裂，这意味着在黑腹毛虫中对复杂生物过程的基础研究直接影响到我们对人类生物学和疾病中可比过程的理解。事实上，大多数与疾病相关的人类基因都与果蝇的基因密切相关。非常活跃的果蝇研究界继续开展大量的基础研究，对于整个科学界的进步来说，有一个中央资源来捕捉、组织和呈现这些信息，这种方式不仅对飞行中的专家，而且对更广泛的研究界来说都是很容易获得的。FlyBase起到了这一作用，并捕获了关于黑腹果蝇基因组和相关基因组的DNA序列及其编码的转录本和蛋白质、经典和转基因突变、表型、菌株集合等的主要信息。这些数据可以作为公共资源、不受限制地通过互联网或以批量下载的方式访问，并经过组织，以便能够对果蝇文献和基因组项目进行复杂的查询。基于从科学文献和大规模数据生产者获得的信息，FlyBase项目未来5年的具体目标将包括：(1)根据编码产物以及DNA上调节基因表达和染色体结构的位置，捕捉、组织和展示一套全面的果蝇基因组序列注释，(2)关于基因及其突变等位基因的基本遗传学的信息，以及(3)第1项和第2项中描述的基本遗传/基因组对象之间的关系，例如，它们在染色体和序列图上的位置，它们的相互作用产生细胞、组织和整个生物体的调节电路，它们在空间和时间上的解剖分布，以及它们在种群和表型类中的变化。

DESCRIPTION (provided by applicant): FlyBase is a database of the core genetic and genomic information on the major genetic model organism, the fruit fly, Drosophila melanogaster, and related organisms of the family Drosophilidae. D. melanogaster has been, and continues to be the pioneering organism in understanding the intricate interplay of genes and their encoded products to drive complex biological processes such as the formation of the body plan of an embryo or the wiring of the nervous system. The evidence that such complex biological events has an ancient origin, predating the split of the insect and vertebrate lineages, means that the fundamental studies on complex biological processes that are carried out in D. melanogaster directly impact on our understanding of comparable processes in human biology and disease. Indeed, the majority of human genes associated with disease have closely related genes in Drosophila. The very vibrant Drosophila research community continues to carry out a great deal of fundamental research, and it is imperative to the progress of the scientific community as a whole that there is a central resource that captures, organizes and presents this information in a way that is readily accessible not only to experts in the fly, but to the broader research community. FlyBase serves that role, and captures the primary information on the DNA sequence of the D. melanogaster genome and related genomes, as well as its encoded transcripts and proteins, classical and transgenic mutations, phenotypes, strain collections, etc. These data can be accessed as a public resource, without restriction, by means of the Internet or as bulk downloads, and are organized so that complex queries of the Drosophila literature and genome projects can be carried out. Specific goals for the next 5 years of the FlyBase project, based on information garnered from the scientific literature and from large-scale data producers, will include capture, organization and presentation of: (1) a comprehensive set of annotations attached to the Drosophila genomic sequence, both in terms of the encoded products as well as the sites on the DNA that mediate regulation of gene expression and the architecture of chromosomes, (2) information on the basic genetics of genes and their mutant alleles, and (3) the relationship of the fundamental genetic/genomic objects described in items 1 and 2 to each other, e.g., their location on chromosomal and sequence maps, their interactions to produce the regulatory circuitry of cells, tissues and whole organisms, their anatomical distribution, both spatially and temporally, and their variation in populations and phenotypic classes.