FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE

简介（申请人提供）：FlyBase是重要生物医学模型果蝇及其相关种的核心基因组/遗传模型生物数据库（MOD）。果蝇是首要的动物研究系统之一，可以非常经济有效地用于帮助理解人类遗传疾病的病因学，并且是最接近的实验模型，可以提供对人类疾病昆虫载体生物学的见解（例如携带疟疾等主要传染病的蚊子）。西尼罗河病毒。目标有两个：(1)为果蝇遗传/基因组数据和实验试剂提供一个集中的资源，以使果蝇研究尽可能快地推进；(2)将这些结果提供给更广泛的生物医学研究界，以进一步他们自己的研究。通过FlyBase管理员的注释、直接用户提交和自动文本挖掘，FlyBase从主要科学文献、大规模基因组分析和功能基因组社区资源项目中获取数据。FlyBase和协作信息学资源广泛共享数据，从而利用每个组的输出。这些异构数据按照一系列本体组织系统被组织成连贯的数据集，并集成到一个中央数据库中。每两个月，这些数据从FlyBase中央数据库中提取出来，并通过一个免费访问的FlyBase网站提供给整个科学界，该网站每月被访问数百万次。除了向研究社区提供FlyBase捕获的数据语料库，这些数据可以很容易地查询和浏览，FlyBase还维护着数百万个与其他生物医学网站的链接，这些网站提供其他相关信息。在拟议的5年拨款期内，FlyBase希望为增强国防部的互操作性做出贡献，并与广泛的信息学资源和期刊出版商合作，为生物医学研究界提供尽可能丰富的数据和数据挖掘工具。

DESCRIPTION (provided by applicant): FlyBase is the core genomic / genetic Model Organism Database (MOD) for the important biomedical model, Drosophila melanogaster and related species of flies. Drosophila is one of the premiere animal research systems and can be used very cost-effectively to help understand the etiology of human genetic diseases and is the closest experimental model that care provide insights into the biology of insect vectors of human disease (such as mosquitos that carry major infectious diseases such as malaria. West Nile Virus. The goals are twofold: (1) to provide a centralized resource for Drosophila genetic/genomic data and experimental reagents in order to enable Drosophila research to advance as rapidly as possible and (2) to provide these results to the broader biomedical research community to further their own research. FlyBase captures data from the primary scientific literature and from large-scale genome analysis and functional genomics community resource projects through annotation by FlyBase curators, direct user submissions and automated text-mining. FlyBase and collaborating informatics resources extensively share data thereby leveraging the output of each group. These heterogeneous data are organized into coherent datasets and integrated in a central database according to a series of ontology organizing systems. On a bi-monthly basis, these data are extracted from the central FlyBase database and served to the entire scientific community through a freely accessible FlyBase website, which is accessed millions of times each month. In addition to providing the research community to ttie corpus of FlyBase-captured data in ways that can be readily interrogated and browsed, FlyBase also maintains millions of links to other biomedical websites providing other relevant information. Over the proposed 5-year grant period, FlyBase expects to contribute to the enhancement of MOD interoperability and to work with a broad range of informatics resources and journal publishers to provide as rich a set of data and data-mining tools as possible to the biomedical research community. RELEVANCE: FlyBase provides crucial data and informatic infrastructure to accelerate the pace of Drosophila research and for the broader biomedical sciences community to leverage these discoveries to further their own research. Drosophila is now a well-accepted experimental model for human disease research and is the closest genetic / genomic experimental model system for research on the insect vectors that carry human diseases.