FLYBASE--A DROSOPHILA GENOMIC AND GENETIC DATABASE

果蝇是最重要的模式生物之一 对于现代生物学研究的许多方面，特别是对于问题 关于后生动物的生物学。比较研究清楚地表明 证明了代谢、细胞和发育调节 在动物王国内，网络是高度保守的，在许多 案件，甚至到其他分类群。尤其是因为世故的 研究最多的果蝇--黑腹果蝇的遗传学 果蝇物种，它带头阐明了许多 小路。哺乳动物系统中的许多工作，特别是老鼠和人类， 完全建立在果蝇强大的基础上 研究提供了。我们现在正处在这样的时刻，我们开始 了解许多角色的生理角色，当这些角色 突变，导致人类疾病。在许多情况下，洞察力会浮出水面 很大程度上来自对这些基因的果蝇同源基因的研究。去拿 最大限度地利用现有信息的信息优势 果蝇，两者都是果蝇，都是果蝇研究人员 对于研究其他生物体的科学家来说，数据是至关重要的 在飞行中被组织起来，并被广泛的生物界所接近。 这就是Flybase联盟的作用。在此应用程序中，FlyBase 要求提供5年的资金，以继续努力提供 拥有基本的基因组和遗传信息的科学界 D.黑腹蛇和其他Drosoliped。这一信息将继续 可通过Flybase WWW服务器在线访问，镜像地址为 世界各地的几个地点。的一个重要的新方面 该项目是伯克利分校公共信息学团队和 欧洲果蝇基因组与最初的FlyBase小组合作 成为一个扩大的FlyBase联盟。这个新的FlyBase联盟将 为社区提供所有果蝇的完全统一的视图 来自整个生物体和种群结构的遗传和基因组数据 深入到序列级别的信息。扩大后的项目将涉及 5个数据采集参与点之间的密切协调， 管理、组织和展示。的重要功能 研究社区将重新组织WWW服务器和一个 实现了各种新的工具，包括许多基于Java的 图形显示。生物数据库需要解决的一个问题是 如何有效地实现它们之间的互联。问题： 相互联系是至关重要的，因为只有一小部分相关的生物学 可以存放在单个存储库中。FlyBase将继续其 在促进互联互通方面的历史性领导作用：通过工作 与其他组织合作生产允许数据交换的软件 在数据库之间，通常通过促进共同努力来实现 满足科学界的需求。

The fruit fly, Drosophila, is one of the most important model organisms for many aspects of modern biological research, especially for issues regarding the biology of metazoa. Comparative studies have clearly demonstrated that the metabolic, cellular, and developmental regulatory networks are highly conserved within the animal kingdom, and in many cases, even to other taxa. Particularly because of the sophisticated genetics of the fruit fly, Drosophila melanogaster, the best-studied drosophilid species, it has led the way in elucidating many of the pathways. Much work in mammalian systems, especially the mouse and humans, has been completely based on the strong foundation that Drosophila research has provided. We are now at the point were we are beginning to understand the physiological roles of many of the roles that, when mutated, contribute to human disease. In many cases, the insights emerge largely from work on the Drosophila cognates of these genes. To take maximum advantage of the information of the information available for Drosophila, both for the Drosophila, both for the Drosophila researcher and for scientists working on other organisms, it is essential that data on the fly be organized and accessible to the broad biological community. This is the role of the Flybase Consortium. In this application, FlyBase requests 5 years of funding to continue its effort to provide the scientific community with the essential genomic and genetic information on D. melanogaster, and other drosolipids. This information will continue to be readily accessible on-line through the Flybase WWW server, mirrored at several sites throughout the world. An important new aspect of the project is the merger of the public informatics teams of the Berkeley and European Drosophila Genome Projects with the original FlyBase group to become an expanded FlyBase Consortium. This new FlyBase Consortium will provide the community with a completely unified view of all Drosophila genetic and genomic data from the whole organism and population structure information down to the sequence level. The expanded project will involve close coordination among the 5 participating sites of data capture, management, organization and presentation. Important features for the research community will be a re-organization of the WWW server and a implementation of a variety of new tools, including many Java-based graphical displays. One issue for the biological databases to address is how to interconnect effectively among themselves. Issue of interconnectivity are crucial, as only a fraction of the relevant biology can be housed in a single repository. FlyBase will continue in its historic leadership role in promoting interconnections: through working with other groups to produce software that will permit data exchange between databases, and generally through contributing to a joint effort to address the needs of the scientific community.