Local Strategies for Schistosomiasis Control

描述：（由申请人提供）：我们的长期目标 研究计划是设计情况和/或网站的具体战略， 抑制环境介导的传染病。立即 这里讨论的问题是确定是否传输的强度 日本血吸虫可以通过使用数学模型 模型，基于本地数据和传输的一般知识 周期，以设计有效的干预措施。这个项目的具体施舍 主要有：1.模型开发：进一步开发血吸虫病模型 传播，基于与艾滋病相关的风险群体，以更有效地 利用通常在中国收集的特定地点的现场数据以及 与疾病传播有关的空间因素， GPS技术。2.使用模型进行设计：设计有效的控制 方案在两个地点选出的四到六个村庄实施。的第一阶段 这项工作将收集三个村庄的标准实地数据集， 成都以西的长丘山，以补充可从 对邛海湖村的目标进行了全面的实地标定 完善的模型。3.实施设计：我们建议实施 从具体目标2产生的设计，并评估这些结果 村庄，如果使用传统方法进行可持续的环境干预， 如果没有出现，我们将确定成功的障碍是否根源于 知识不足，技术限制或农业实践。

DESCRIPTION: (provided by the applicant): The long-term objective of our research program is to design situation- and/or site-specific strategies for the suppression of environmentally mediated infectious diseases. The immediate issue addressed here is to determine if the intensity of transmission of Schistosoma japonicum can be predictably diminished by using a mathematical model, based on both local data and general knowledge of the transmission cycle, to design effective interventions. The specific alms of this project are: 1.Model Development: to further develop our model of schistosomiasis transmission, based on exposure-related risk groups, to more effectively utilize site-specific field data typically collected in China as well as data on spatial factors relevant to disease transmission now easily obtained using GPS technology. 2. Use the Model for Design: to design effective control programs in four to six villages selected from two sites. The first phase of this work will be to collect the standard field data set in three villages in the Changqiu Mountains west of Chengdu to supplement that available from the Qionghai Lake villages with the objective of full site-specific calibration of the refined model. 3. Implement the Designs: we propose to implement the designs resulting from Specific Aim 2 and evaluate the results in these villages, if sustainable environmental interventions using traditional methods do not emerge, we will determine whether the impediments to success are rooted in inadequate knowledge, technological limitations, or agricultural practices.