Local Strategies for Schistosomiasis Control

当地血吸虫病控制策略

• 批准号: 6415018
• 负责人: ROBERT C SPEAR
• 金额: $ 32.67万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6415018
• 关键词: China; Gastropoda; Rodentias; Schistosoma japonicum; bioassay; clinical research; communicable disease transmission; disease /disorder prevention /control; disease /disorder proneness /risk; emerging infectious disease; environmental exposure; environmental protection; field study; human subject; mathematical model; patient oriented research; questionnaires; schistosomiasis; technology /technique development

DESCRIPTION: (provided by the applicant): The long-term objective of our research program is to design situation- and/or site-specific strategies for the suppression of environmentally mediated infectious diseases. The immediate issue addressed here is to determine if the intensity of transmission of Schistosoma japonicum can be predictably diminished by using a mathematical model, based on both local data and general knowledge of the transmission cycle, to design effective interventions. The specific alms of this project are: 1.Model Development: to further develop our model of schistosomiasis transmission, based on exposure-related risk groups, to more effectively utilize site-specific field data typically collected in China as well as data on spatial factors relevant to disease transmission now easily obtained using GPS technology. 2. Use the Model for Design: to design effective control programs in four to six villages selected from two sites. The first phase of this work will be to collect the standard field data set in three villages in the Changqiu Mountains west of Chengdu to supplement that available from the Qionghai Lake villages with the objective of full site-specific calibration of the refined model. 3. Implement the Designs: we propose to implement the designs resulting from Specific Aim 2 and evaluate the results in these villages, if sustainable environmental interventions using traditional methods do not emerge, we will determine whether the impediments to success are rooted in inadequate knowledge, technological limitations, or agricultural practices.

描述：（由申请人提供）：我们的长期目标 研究计划是设计针对具体情况和/或地点的策略 抑制环境介导的传染病。即时的 这里解决的问题是确定传输的强度是否 通过使用数学方法可以预见地减少日本血吸虫 模型，基于本地数据和传输的一般知识 循环，设计有效的干预措施。本项目具体捐赠情况 主要有： 1.模型开发：进一步开发我们的血吸虫病模型 根据与暴露相关的风险群体，更有效地传播 利用通常在中国收集的特定地点的现场数据以及数据 现在可以轻松获得与疾病传播相关的空间因素 GPS技术。 2. 使用模型进行设计：设计有效的控制 从两个地点选出的四到六个村庄的项目。第一阶段 这项工作将收集三个村庄的标准实地数据集 成都以西的长丘山脉，以补充从 邛海湖村落目标全面定点标定 精致的模型。 3. 实施设计：我们建议实施 由具体目标 2 产生的设计并评估这些结果 村庄，如果使用传统方法进行可持续的环境干预 如果没有出现，我们将确定成功的障碍是否有根源 知识不足、技术限制或农业实践。