Local Strategies for Schistosomiasis Control

描述：(申请人提供)：我们的长期目标是 研究计划旨在设计针对具体情况和/或现场的策略 抑制环境传播的传染病。最直接的 这里讨论的问题是确定传播的强度是否 日本血吸虫可以通过使用一种数学方法来预测减少 模型，基于本地数据和传输的一般知识 周期，以设计有效的干预措施。这个项目的具体施舍 1.模型开发：进一步发展我们的血吸虫病模型 根据与接触有关的风险群体，向更有效地 利用通常在中国收集的特定地点的现场数据以及数据 关于与疾病传播相关的空间因素现在很容易使用 GPS技术。2.使用设计模型：设计有效的控制 从两个地点选出的四到六个村庄的节目。第一阶段 这项工作将收集在三个村庄的标准现场数据集 成都以西的长丘山补充说，可以从 琼海湖村庄的目标是全面的特定地点校准 精致的模型。3.落实设计：我们建议实施 由特定目标2产生的设计，并评估这些设计的结果 村庄，如果使用传统方法进行可持续的环境干预 如果不出现，我们将确定成功的障碍是否根深蒂固 在知识不足、技术限制或农业实践方面。

DESCRIPTION: (provided by the applicant): The long-term objective of our research program is to design situation- and/or site-specific strategies for the suppression of environmentally mediated infectious diseases. The immediate issue addressed here is to determine if the intensity of transmission of Schistosoma japonicum can be predictably diminished by using a mathematical model, based on both local data and general knowledge of the transmission cycle, to design effective interventions. The specific alms of this project are: 1.Model Development: to further develop our model of schistosomiasis transmission, based on exposure-related risk groups, to more effectively utilize site-specific field data typically collected in China as well as data on spatial factors relevant to disease transmission now easily obtained using GPS technology. 2. Use the Model for Design: to design effective control programs in four to six villages selected from two sites. The first phase of this work will be to collect the standard field data set in three villages in the Changqiu Mountains west of Chengdu to supplement that available from the Qionghai Lake villages with the objective of full site-specific calibration of the refined model. 3. Implement the Designs: we propose to implement the designs resulting from Specific Aim 2 and evaluate the results in these villages, if sustainable environmental interventions using traditional methods do not emerge, we will determine whether the impediments to success are rooted in inadequate knowledge, technological limitations, or agricultural practices.