MICHIGAN CENTER FOR THE ENVIRONMENT AND CHILDRENS HEALTH

密歇根环境与儿童健康中心

• 批准号: 6322333
• 负责人: BARBARA Anne ISRAEL
• 金额: $ 67.41万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-11-01 至 2003-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6322333
• 关键词: asthma; environmental toxicology

Childhood asthma is one of the most common chronic pediatric diseases and poses a serious public health problem. The prevalence of the disease in the city of Detroit if particularly high, reflecting the trends found elsewhere among urban populations and communities of color. The Michigan Center for the Environment and Children's Health will investigate environmental, pathophysiological, and clinical mechanisms of pediatric asthma which will translate into risk assessment and comprehensive neighborhood and household interventions. Three research cores, Asthma Intervention (Core 1), Asthma Exposure (Core 2) and Asthma Chemokines (Core 3), supported by two Facility Cores (Biostatistics and Exposure Assessment) and two new Center Scientists, will engage in coordinated interdisciplinary research aimed at: 1. increasing knowledge and behavior to reduce environmental hazards in households and neighborhoods, thereby improving asthma-related health status, 2) examination of the effects of daily and seasonal fluctuations in indoor and outdoor ambient air quality on pulmonary function and severity of asthma symptoms, and 3) determination of the effects of allergen-induced local, excessive production of chemokines on redox status and innervation of the bronchial tress. The Center is a partnership between the University of Michigan, community-based organizations and health care institutions in Detroit and focuses on jointly identified problems, research strategies and interventions design. The activities of the proposed Center are predicted on the bi-directional flow of interventions design. The activities of the proposed Center are predicted on the bi-directional flow of information from the basic research cores to the community-based intervention core and vice versa. It is anticipated that the Michigan Center for the Environment and Children's Health will fill existing gaps in knowledge of the relationships between environmental factors and clinico-pathophysiological aspects of pediatric asthma, and will provide a sound scientific and culturally sensitive framework for conducting effective prevention intervention research.

儿童哮喘是最常见的慢性儿科疾病之一 造成严重的公共卫生问题。该病的患病率在 底特律市如果特别高，反映了发现的趋势 其他地方的城市人口和有色人种社区。密歇根州 环境与儿童健康中心将进行调查 儿科疾病的环境、病理生理和临床机制 哮喘，这将转化为风险评估和综合 邻里和家庭干预。三大研究核心，哮喘 干预（核心 1）、哮喘暴露（核心 2）和哮喘趋化因子 （核心 3），由两个设施核心（生物统计和暴露）支持 评估）和两名新的中心科学家，将参与协调 跨学科研究的目的是： 1. 增加知识和行为 减少家庭和社区的环境危害，从而 改善哮喘相关的健康状况，2）检查效果 室内外环境空气质量的每日和季节性波动 肺功能和哮喘症状的严重程度，以及 3) 确定过敏原引起的局部、过量的影响 氧化还原状态和支气管神经支配的趋化因子的产生 头发。该中心是密歇根大学、 底特律的社区组织和医疗保健机构 重点关注共同确定的问题、研究策略和 干预设计。预计拟议中心的活动 关于干预设计的双向流程。该组织的活动 所提出的中心是根据双向信息流进行预测的 从基础研究核心到社区干预核心 反之亦然。预计密歇根环境中心 和儿童健康将填补现有的知识空白 环境因素与临床病理生理的关系 儿科哮喘方面的问题，并将提供完善的科学和 进行有效预防的文化敏感框架 干预研究。