MICHIGAN CENTER FOR THE ENVIRONMENT AND CHILDRENS HEALTH

密歇根环境与儿童健康中心

• 批准号: 6873156
• 负责人: BARBARA Anne ISRAEL
• 金额: $ 15.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-11-01 至 2004-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6873156
• 关键词: asthma; environmental toxicology

Childhood asthma is one of the most common chronic pediatric diseases and poses a serious public health problem. The prevalence of the disease in the city of Detroit if particularly high, reflecting the trends found elsewhere among urban populations and communities of color. The Michigan Center for the Environment and Children's Health will investigate environmental, pathophysiological, and clinical mechanisms of pediatric asthma which will translate into risk assessment and comprehensive neighborhood and household interventions. Three research cores, Asthma Intervention (Core 1), Asthma Exposure (Core 2) and Asthma Chemokines (Core 3), supported by two Facility Cores (Biostatistics and Exposure Assessment) and two new Center Scientists, will engage in coordinated interdisciplinary research aimed at: 1. increasing knowledge and behavior to reduce environmental hazards in households and neighborhoods, thereby improving asthma-related health status, 2) examination of the effects of daily and seasonal fluctuations in indoor and outdoor ambient air quality on pulmonary function and severity of asthma symptoms, and 3) determination of the effects of allergen-induced local, excessive production of chemokines on redox status and innervation of the bronchial tress. The Center is a partnership between the University of Michigan, community-based organizations and health care institutions in Detroit and focuses on jointly identified problems, research strategies and interventions design. The activities of the proposed Center are predicted on the bi-directional flow of interventions design. The activities of the proposed Center are predicted on the bi-directional flow of information from the basic research cores to the community-based intervention core and vice versa. It is anticipated that the Michigan Center for the Environment and Children's Health will fill existing gaps in knowledge of the relationships between environmental factors and clinico-pathophysiological aspects of pediatric asthma, and will provide a sound scientific and culturally sensitive framework for conducting effective prevention intervention research.

儿童哮喘是儿科最常见的慢性疾病之一， 造成了严重的公共卫生问题。该病在中国的流行情况 底特律的城市如果特别高，反映出的趋势发现 在城市人口和有色人种社区的其他地方。密歇根州 环境和儿童健康中心将调查 儿科疾病的环境、病理生理和临床机制 哮喘，将转化为风险评估和综合 邻里和家庭干预。三个研究中心，哮喘 干预(核心1)、哮喘暴露(核心2)和哮喘趋化因子 (核心3)，由两个设施核心(生物统计和曝光)支持 评估)和两名新的中心科学家将进行协调 跨学科研究的目标是：1.增加知识和行为 减少家庭和邻里的环境危害，从而 改善与哮喘相关的健康状况，2)检查 室内和室外环境空气质量的每日和季节波动 肺功能与哮喘症状严重程度的关系，3) 过敏原诱导的局部、过度影响的测定 支气管氧化还原状态和神经支配过程中趋化因子的产生 特雷斯特。该中心是密歇根大学与 底特律和美国的社区组织和保健机构 重点关注共同发现的问题、研究策略和 干预措施设计。对拟建中心的活动进行了预测 关于双向流动干预措施的设计。本组织的活动 建议的中心是对信息双向流动的预测 从基础研究核心到社区干预核心和 反之亦然。预计密歇根环境中心 和儿童健康将填补现有的知识空白 环境因素与临床病理生理的关系 儿童哮喘的方方面面，并将提供健全的科学和 进行有效预防的文化敏感框架 干预研究。

项目成果

Social and physical environments and disparities in risk for cardiovascular disease: the healthy environments partnership conceptual model.

• DOI: 10.1289/ehp.7913
• 发表时间: 2005-12
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Schulz AJ;Kannan S;Dvonch JT;Israel BA;Allen A 3rd;James SA;House JS;Lepkowski J
• 通讯作者: Lepkowski J

Effect of air pollution control on life expectancy in the United States: an analysis of 545 U.S. counties for the period from 2000 to 2007.

• DOI: 10.1097/ede.0b013e3182770237
• 发表时间: 2013-01
• 期刊: Epidemiology (Cambridge, Mass.)
• 作者: Correia AW;Pope CA 3rd;Dockery DW;Wang Y;Ezzati M;Dominici F
• 通讯作者: Dominici F

Air pollution-associated changes in lung function among asthmatic children in Detroit.

• DOI: 10.1289/ehp.7533
• 发表时间: 2005-08
• 期刊: Environmental health perspectives
• 影响因子: 10.4

Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice.

• DOI: 10.1186/1465-9921-7-129
• 发表时间: 2006-10-17
• 期刊: Respiratory research
• 影响因子: 5.8
• 作者: McKinley L;Kim J;Bolgos GL;Siddiqui J;Remick DG
• 通讯作者: Remick DG

Acute effects of ambient particulate matter on blood pressure: differential effects across urban communities.

• DOI: 10.1161/hypertensionaha.108.123877
• 发表时间: 2009-05
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Dvonch JT;Kannan S;Schulz AJ;Keeler GJ;Mentz G;House J;Benjamin A;Max P;Bard RL;Brook RD
• 通讯作者: Brook RD