MICHIGAN CENTER FOR THE ENVIRONMENT AND CHILDRENS HEALTH

儿童哮喘是儿科最常见的慢性疾病之一， 会造成严重的公共卫生问题该疾病的患病率在 底特律市如果特别高，反映了发现的趋势 在城市人口和有色人种社区中。密歇根 环境和儿童健康中心将调查 环境、病理生理和临床机制， 哮喘，这将转化为风险评估和全面的 邻里和家庭干预。三个研究核心，哮喘 干预（核心1）、哮喘暴露（核心2）和哮喘趋化因子 (Core 3），由两个设施核心（生物统计和暴露）支持 评估）和两名新的中心科学家，将从事协调 跨学科研究的目的是：1。增加知识和行为 减少家庭和社区的环境危害， 改善哮喘相关的健康状况，2）检查 室内和室外环境空气质量的每日和季节性波动 肺功能和哮喘症状的严重程度，以及3） 确定过敏原引起的局部、过度 趋化因子的产生对支气管氧化还原状态和神经支配的影响 发。该中心是密歇根大学， 底特律的社区组织和医疗机构， 重点是共同确定的问题，研究战略， 干预设计。预测了拟建中心的活动 关于干预设计的双向流动。的活动 建议中心预测的双向流动的信息 从基础研究核心到社区干预核心， 反之亦然据估计，密歇根州环境中心 儿童健康将填补现有的知识空白， 环境因素与临床病理生理的关系 儿童哮喘方面，并将提供一个健全的科学和 进行有效预防的文化敏感框架 干预研究

Childhood asthma is one of the most common chronic pediatric diseases and poses a serious public health problem. The prevalence of the disease in the city of Detroit if particularly high, reflecting the trends found elsewhere among urban populations and communities of color. The Michigan Center for the Environment and Children's Health will investigate environmental, pathophysiological, and clinical mechanisms of pediatric asthma which will translate into risk assessment and comprehensive neighborhood and household interventions. Three research cores, Asthma Intervention (Core 1), Asthma Exposure (Core 2) and Asthma Chemokines (Core 3), supported by two Facility Cores (Biostatistics and Exposure Assessment) and two new Center Scientists, will engage in coordinated interdisciplinary research aimed at: 1. increasing knowledge and behavior to reduce environmental hazards in households and neighborhoods, thereby improving asthma-related health status, 2) examination of the effects of daily and seasonal fluctuations in indoor and outdoor ambient air quality on pulmonary function and severity of asthma symptoms, and 3) determination of the effects of allergen-induced local, excessive production of chemokines on redox status and innervation of the bronchial tress. The Center is a partnership between the University of Michigan, community-based organizations and health care institutions in Detroit and focuses on jointly identified problems, research strategies and interventions design. The activities of the proposed Center are predicted on the bi-directional flow of interventions design. The activities of the proposed Center are predicted on the bi-directional flow of information from the basic research cores to the community-based intervention core and vice versa. It is anticipated that the Michigan Center for the Environment and Children's Health will fill existing gaps in knowledge of the relationships between environmental factors and clinico-pathophysiological aspects of pediatric asthma, and will provide a sound scientific and culturally sensitive framework for conducting effective prevention intervention research.