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Virus Host Interactions and Virion Assembly

Virus Host Interactions and Virion Assembly
病毒宿主相互作用和病毒粒子组装
批准号：
6506853
负责人：
BERNARD MOSS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6506853
关键词：
cell cell interaction confocal scanning microscopy electron microscopy host organism interaction immunoelectron microscopy laboratory mouse laboratory rabbit membrane proteins membrane reconstitution /synthesis polymerase chain reaction protein protein interaction protein sequence recombinant virus vaccinia virus virion virus assembly virus envelope virus genetics virus infection mechanism virus protein virus replication

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中文摘要
翻译
牛痘病毒的有效感染包括进入细胞；基因组的表达和复制；针对特定和非特定宿主免疫机制的防御；以及具有感染性的、被包裹的病毒颗粒的组装和释放。其中许多步骤涉及病毒蛋白与细胞蛋白或细胞膜的相互作用。遗传学、生物化学和电子显微镜相结合的方法被用来研究这些复杂的过程。在过去的一年里，重点是了解细胞内和细胞外病毒粒子的形成和传播步骤，痘病毒的宿主范围限制，以及病毒免疫防御蛋白。
英文摘要
A productive infection by vaccinia virus involves entry into the cell; expression and replication of the genome; defense against specific and non-specific host immune mechanisms; and assembly and release of infectious, enveloped, virus particles. Many of these steps involve interactions of viral proteins with cellular proteins or membranes. Combined genetic, biochemical, and electron microscopic approaches are being used to investigate these complex processes. During the past year, emphasis has been on understanding the steps in the formation and transmission of intracellular and extracellular virions, the host range restriction of poxviruses, and viral immune defense proteins.
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VIRUS HOST INTERACTIONS
REGULATION OF VACCINIA VIRUS GENE EXPRESSION
Development of Vaccinia Virus as an Expression Vector
Recombinant and Attenuated Vaccines
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