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REGULATION OF VACCINIA VIRUS GENE EXPRESSION

REGULATION OF VACCINIA VIRUS GENE EXPRESSION
痘苗病毒基因表达的调控
批准号：
6098907
负责人：
BERNARD MOSS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6098907
关键词：
Baculoviridae electron microscopy gene expression gene targeting genetic promoter element genetic regulation laboratory rabbit open reading frames recombinant DNA recombinant virus tissue /cell culture transcription factor vaccinia virus virus genetics virus infection mechanism

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英文摘要
Poxviruses encode enzymes and factors needed for transcription of their genomes within the cytoplasm of infected cells. Vaccinia virus, the prototypic member of the poxvirus family, provides a unique system for combining biochemical and genetic approaches for investigating mechanisms of gene regulation and mRNA biosynthesis. Studies with vaccinia virus indicated that the genes are divided into three temporal classes - early, intermediate and late. Each gene class has a consensus DNA promoter sequence and corresponding transcription factors that interact with the virus-encoded multisubunit RNA polymerase. The transcription system for early genes is packaged within the infectious virus particle during its assembly, whereas the factors for intermediate and late gene transcription are synthesized successively after infection.
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VIRUS HOST INTERACTIONS
REGULATION OF VACCINIA VIRUS GENE EXPRESSION
Development of Vaccinia Virus as an Expression Vector
Poxvirus Entry, Assembly, and Dissemination
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