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MOLLUSCUM CONTAGIOSUM VIRUS

MOLLUSCUM CONTAGIOSUM VIRUS
传染性软疣病毒
批准号：
6431644
负责人：
BERNARD MOSS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6431644
关键词：
Poxviridae gene expression genome host organism interaction human tissue nucleic acid sequence plasmids virus characteristic virus genetics virus infection mechanism

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中文摘要
翻译
传染性软疣病毒(MCV)是一种人痘病毒，可导致无症状的皮肤肿瘤，可在健康或免疫缺陷者的皮肤上持续数月至数年，尤其是儿童。这种病毒的持续感染正在增加，并已成为成年艾滋病患者的麻烦并发症。目前还没有针对这种疾病的具体预防或治疗方法。所有培养这种病毒的尝试都失败了，人们对它知之甚少。该项目的目标是分析病毒基因组的结构，识别其基因，确定其表达和复制模式，并找到它用于防御宿主免疫系统的机制。
英文摘要
Molluscum contagiosum virus (MCV) is a human poxvirus that causes asymptomatic cutaneous neoplasms that can persist for months to years in the skin of healthy or immunodeficient individuals, particularly children. Persistent infections with this virus are increasing and have become troublesome complications for adults with AIDS. At present there is no specific preventive or treatment for the disease. All attempts to culture the virus have failed and little is known about it. The objectives of the project are to analyze the structure of the viral genome, identify its genes, determine its mode of expression and replication, and find the mechanisms that it uses for defense against the host immune system.
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会议论文
VIRUS HOST INTERACTIONS
REGULATION OF VACCINIA VIRUS GENE EXPRESSION
Development of Vaccinia Virus as an Expression Vector
Poxvirus Entry, Assembly, and Dissemination
海外基金