MOLLUSCUM CONTAGIOSUM VIRUS

传染性软疣病毒

• 批准号: 6431644
• 负责人: BERNARD MOSS
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6431644
• 关键词: Poxviridae; gene expression; genome; host organism interaction; human tissue; nucleic acid sequence; plasmids; virus characteristic; virus genetics; virus infection mechanism

Molluscum contagiosum virus (MCV) is a human poxvirus that causes asymptomatic cutaneous neoplasms that can persist for months to years in the skin of healthy or immunodeficient individuals, particularly children. Persistent infections with this virus are increasing and have become troublesome complications for adults with AIDS. At present there is no specific preventive or treatment for the disease. All attempts to culture the virus have failed and little is known about it. The objectives of the project are to analyze the structure of the viral genome, identify its genes, determine its mode of expression and replication, and find the mechanisms that it uses for defense against the host immune system.

传染性软疣病毒（MCV）是一种人类痘病毒，可引起无症状的皮肤肿瘤，这种肿瘤可在健康或免疫缺陷个体（尤其是儿童）的皮肤中持续数月至数年。这种病毒的持续感染正在增加，并已成为成年艾滋病患者的棘手并发症。目前尚无特效的预防或治疗方法。所有培养病毒的尝试都失败了，对它知之甚少。该项目的目标是分析病毒基因组的结构，鉴定其基因，确定其表达和复制模式，并找到它用于防御宿主免疫系统的机制。