Recombinant and Attenuated Vaccines

重组疫苗和减毒疫苗

• 批准号: 7192847
• 负责人: BERNARD MOSS
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7192847
• 关键词: AIDS vaccines; HIV infections; Poxviridae disease; Primates; SARS virus; attenuated microorganism; biotechnology; bioterrorism /chemical warfare; communicable disease control; enzyme linked immunosorbent assay; flow cytometry; human immunodeficiency virus; laboratory mouse; live vaccine; nucleic acid sequence; recombinant virus; severe acute respiratory syndrome; smallpox vaccine; smallpox virus; transfection /expression vector; vaccine development; vaccinia virus; vector vaccine; viral vaccines; virus DNA; virus antigen

There are many diseases for which there are no vaccines and others for which the vaccines are not optimal or have significant side effects. The objectives of this project are to characterize viral antigens, determine targets of humoral and cell mediated immunity, and to use this information to develop candidate vaccines. Both live recombinant vaccines and recombinant protein vaccines are being developed. The vaccines are first tested in small animals and then in non-human primates. Presently we are working on vaccines for HIV, SARS, and smallpox.

有许多疾病没有疫苗，而其他疾病的疫苗不是最佳的或有显着的副作用。该项目的目标是表征病毒抗原，确定体液和细胞介导的免疫的靶标，并利用这些信息开发候选疫苗。重组活疫苗和重组蛋白疫苗都正在开发中。这些疫苗首先在小动物中进行测试，然后在非人类灵长类动物中进行测试。目前我们正在研究艾滋病毒、非典和天花的疫苗。