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Recombinant and Attenuated Vaccines

Recombinant and Attenuated Vaccines
重组疫苗和减毒疫苗
批准号：
7192847
负责人：
BERNARD MOSS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7192847
关键词：
AIDS vaccinesHIV infectionsPoxviridae diseasePrimatesSARS virusattenuated microorganismbiotechnologybioterrorism /chemical warfarecommunicable disease controlenzyme linked immunosorbent assayflow cytometryhuman immunodeficiency viruslaboratory mouselive vaccinenucleic acid sequencerecombinant virussevere acute respiratory syndromesmallpox vaccinesmallpox virustransfection /expression vectorvaccine developmentvaccinia virusvector vaccineviral vaccinesvirus DNAvirus antigen

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中文摘要
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英文摘要
There are many diseases for which there are no vaccines and others for which the vaccines are not optimal or have significant side effects. The objectives of this project are to characterize viral antigens, determine targets of humoral and cell mediated immunity, and to use this information to develop candidate vaccines. Both live recombinant vaccines and recombinant protein vaccines are being developed. The vaccines are first tested in small animals and then in non-human primates. Presently we are working on vaccines for HIV, SARS, and smallpox.
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VIRUS HOST INTERACTIONS
REGULATION OF VACCINIA VIRUS GENE EXPRESSION
Development of Vaccinia Virus as an Expression Vector
Poxvirus Entry, Assembly, and Dissemination
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