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Virus Host Interactions and Virion Assembly

Virus Host Interactions and Virion Assembly
病毒宿主相互作用和病毒粒子组装
批准号：
6985723
负责人：
BERNARD MOSS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6985723
关键词：
Poxviridaeconfocal scanning microscopyelectron microscopygene expressionhost organism interactionlaboratory mousenucleic acid sequencepolymerase chain reactionvaccinia virusvirionvirus assemblyvirus protein

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中文摘要
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英文摘要
A productive infection by vaccinia virus involves entry into the cell; expression and replication of the genome; defense against specific and non-specific host immune mechanisms; and assembly and release of infectious, enveloped, virus particles. Many of these steps involve interactions of viral proteins with cellular proteins or membranes. Combined genetic, biochemical, and electron microscopic approaches are being used to investigate these complex processes. During the past year, emphasis has been on understanding the steps in the formation and transmission of intracellular and extracellular virions, the host range restriction of poxviruses, and viral immune defense proteins.
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VIRUS HOST INTERACTIONS
REGULATION OF VACCINIA VIRUS GENE EXPRESSION
Development of Vaccinia Virus as an Expression Vector
Poxvirus Entry, Assembly, and Dissemination
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