课题基金 / 基金详情

Molluscum Contagiosum Virus

Molluscum Contagiosum Virus
传染性软疣病毒
批准号：
6506936
负责人：
BERNARD MOSS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6506936
关键词：
AIDS AIDS related neoplasm /cancer Poxviridae gene expression genome host organism interaction nucleic acid sequence polymerase chain reaction skin neoplasms virus characteristic virus genetics virus infection mechanism virus protein

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中文摘要
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英文摘要
Molluscum contagiosum virus (MCV) is a human poxvirus that causes asymptomatic cutaneous neoplasms that can persist for months to years in the skin of healthy or immunodeficient individuals, particularly children. Persistent infections with this virus are increasing and have become troublesome complications for adults with AIDS. At present there is no safe, specific preventive or treatment for the disease. All attempts to culture the virus have failed and little is known about it. The objectives of the project are to analyze the structure of the viral genome, identify its genes, determine its mode of expression and replication, and find the mechanisms that it uses for defense against the host immune system.
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会议论文
VIRUS HOST INTERACTIONS
REGULATION OF VACCINIA VIRUS GENE EXPRESSION
Development of Vaccinia Virus as an Expression Vector
Poxvirus Entry, Assembly, and Dissemination