VIRUS HOST INTERACTIONS

病毒宿主相互作用

• 批准号: 6288871
• 负责人: BERNARD MOSS
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6288871
• 关键词: host organism interaction; immunoelectron microscopy; laboratory rabbit; membrane proteins; monoclonal antibody; protein sequence; recombinant virus; vaccinia virus; virus assembly; virus envelope; virus genetics; virus infection mechanism; virus protein; virus replication

A productive infection by vaccinia virus involves entry into the cell; expression and replication of the genome; defense against specific and non-specific host immune mechanisms; and assembly and release of infectious, enveloped, virus particles. Many of these steps involve interactions of viral proteins with cellular proteins or membranes. Combined genetic, biochemical, and electron microscopic approaches are being used to investigate these complex processes. During the past year, emphasis has been on understanding the steps in the formation and transmission of intracellular and extracellular virions and the host range restriction of poxviruses. - Vaccinia virus, host range, infectivity

牛痘病毒的生产性感染涉及进入细胞；基因组的表达和复制；防御特异性和非特异性宿主免疫机制；以及传染性包膜病毒颗粒的组装和释放。其中许多步骤涉及病毒蛋白与细胞蛋白或细胞膜的相互作用。遗传学、生物化学和电子显微镜相结合的方法被用来研究这些复杂的过程。在过去的一年中，重点是了解细胞内和细胞外病毒粒子的形成和传播的步骤以及痘病毒的宿主范围限制。-牛痘病毒，宿主范围，传染性