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DESCRIPTION (provided by applicant) Iron is essential for many cellular functions, but it is also a potent pro- oxidant that can produce hydroxyl radicals through Fenton chemistry. Ascorbic acid, a very potent scavenger of hydroxyl radicals, can enhance dietary, non- heme iron absorption by increasing the transfer of iron across the apical membrane of intestinal epithelial cells. In the presence of iron, in vitro experiments have shown ascorbic acid to act as a pro-oxidant. Whether ascorbic acid has pro-oxidant activity in vivo continues to be debated. Hereditary hemochromatosis (HH) is a common autosomal recessive disease in which the regulation of intestinal iron absorption is lost. The resulting iron overload is associated with excessive lipid peroxidation. The pattern of p53 mutations in HH is consistent with the mutagenic potential of the DNA adduct, l,N6-ethenodeoxyadenosine. The investigators hypothesize that despite the normal regulation of intestinal iron absorption, ascorbic acid and iron supplementation will lead to sufficient iron overload to increase lipid peroxidation and EdA formation. Furthermore, co-supplementation with iron and ascorbic acid in HH, in which regulation of intestinal iron absorption is lost, will result in worsening the iron overload leading to greater lipid peroxidation, EdA formation and hepatocellular carcinoma. The investigators propose experiments that are designed to examine the interactive effects of dietary iron and ascorbic acid and genetic iron overload on iron loading, lipid peroxidation and mutagenesis. They will use a mouse model of HH that is prone to hepatocellular formation.
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The potentiating and protective effects of ascorbate on oxidative stress depend upon the concentration of dietary iron fed C3H mice.
抗坏血酸对氧化应激的增强和保护作用取决于膳食铁喂养的 C3H 小鼠的浓度。
DOI: 10.1016/j.jnutbio.2006.05.004
发表时间: 2007
期刊: The Journal of nutritional biochemistry
影响因子: --
作者: [Premkumar,Kumpati, Min,Kyungmi, Alkan,Zeynep, Hawkes,WayneC, Ebeler,Susan, Bowlus,ChristopherL]
通讯作者: Bowlus,ChristopherL
SACRAMENTO COLLABORATIVE TO ADVANCE TESTING AND CARE OF HEPATITIS B (SCRATCH)
  • 批准号:
    8876888
  • 项目类别:
  • 资助金额:
    $30.0万
  • 财政年份:
    2014
  • 负责人:
    CHRISTOPHER L. BOWLUS
  • 依托单位:
SACRAMENTO COLLABORATIVE TO ADVANCE TESTING AND CARE OF HEPATITIS B (SCRATCH)
  • 批准号:
    8919153
  • 项目类别:
  • 资助金额:
    $32.67万
  • 财政年份:
    2014
  • 负责人:
    CHRISTOPHER L. BOWLUS
  • 依托单位:
Biologic Basis of Disparity in Liver Cancer Survival Among Asian Americans
  • 批准号:
    8585383
  • 项目类别:
  • 资助金额:
    $16.82万
  • 财政年份:
    2013
  • 负责人:
    CHRISTOPHER L. BOWLUS
  • 依托单位:
Biologic Basis of Disparity in Liver Cancer Survival Among Asian Americans
  • 批准号:
    8735904
  • 项目类别:
  • 资助金额:
    $19.71万
  • 财政年份:
    2013
  • 负责人:
    CHRISTOPHER L. BOWLUS
  • 依托单位:
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