CORE--EPIDEMIOLOGY

描述（由申请人提供）：本研究的总体目标是 描述以下人群的接触情况和相关疾病决定因素： 在农业工作场所接触有毒化学品的人口 最后，本核心鼓励和促进研究，以评估贡献 潜在的有毒农业化学品暴露的症状或疾病， 暴露人群。该研究涉及学科的相互作用 参与疾病发生的流行病学研究、暴露评估 以及毒性暴露、影响和可能途径的表征 传输每个项目都可能涉及其中的部分或全部内容。的 流行病学与接触评估的相互作用（工业卫生） 代表了职业/环境流行病学的传统模式 调查事务所实验室分析与流行病学的结合 数据，有时被称为分子或生物化学流行病学， 研究疾病的决定因素和机制的重要方法 和有害健康的影响。在这些研究中，实验室 调查人员与流行病学家合作， 生物样本和效应标记。例如测量 尿液中的有机磷代谢物是暴露的标志，而评估 尿内分泌标志物是生殖功能的标志物。 某厂接尘工人肺组织病理学调查 从验尸官的病例中获得的已故西班牙裔男性包括两种生物标志物 暴露（肺粉尘含量和成分）和影响（病理变化 肺）。

Description (provided by applicant): The overall goal of this research is to characterize the exposures and associated determinants of disease among populations exposed to toxic chemicals in the agricultural workplace to this end, this Core encourages and facilitates research to assess the contribution of potentially toxic agrochemical exposures to symptoms or disease in the exposed populations. The research involves the interaction of disciplines involved in the epidemiologic study of disease occurrence, exposure assessment and characterization of toxic exposures, effects, and likely routes of transmission. Each project may involve some or all of these components. The interaction of epidemiology with exposure assessment (industrial hygiene) represents a traditional model in occupational/environmental epidemiologic investigations. The integration of laboratory analyses with epidemiologic data, sometimes referred to as molecular or biochemical epidemiology, is also an important approach to studying, the determinants and mechanisms of disease and adverse health effects of exposures. In these studies, the laboratory investigators work with epidemiologists to measure both markers of exposure in biologic specimens, and markers of effect. For example, measurement of organophosphate metabolites in urine is a marker of exposure, while assessment of urinary endocrine markers of reproductive function is a marker of effect. The investigation of dust exposure and pulmonary pathology in lungs from deceased Hispanic males obtained from coroners' cases includes both biomarkers of exposure (lung dust content and composition) and effect (pathologic changes in the lung).