Sleep during the peri-menopause in a multi-ethnic cohort

描述：(申请者提供)这项互动研究项目资助 (IRPG)将表征更年期特征之间的关系 和430名女性的睡眠样本：200名高加索人，150名非裔美国人，以及 80个中国人。尽管睡眠中断、失眠和睡眠发生率 中年女性呼吸紊乱增加，对此知之甚少 更年期与睡眠的关系。血管舒缩症状的影响 关于睡眠的激素替代疗法表明，睡眠更年期 关系不仅仅是年龄的函数。更好地理解 考虑到影响，中年女性睡眠障碍的原因是重要的 睡眠对身心健康的影响。睡眠障碍与 伴随着一系列负面的健康后果，包括生产力和 生活质量、精神疾病发病率、免疫抑制和增加 对疾病和疾病的脆弱性。本研究小组的研究目的是：1) 在中年多种族的大样本中描述睡眠障碍的特征 妇女；2)描述更年期特征和 睡眠障碍；3)评估相关心理生物学的影响 影响睡眠-更年期关系的因素；以及4)建立基线数据 用于未来的纵向研究。正在进行的七个研究地点中的四个 全国女性S健康研究(天鹅)将合作招募一名 天鹅队列中绝经前和围绝经期妇女的样本。一旦注册 在睡眠研究中，参与者将在新的 月经周期。将在#年进行动态多导睡眠监测 参与者在协议的第1-3天回家。睡眠日记，活动记录仪， 并将收集血管运动症状数据的事件监视器记录 在整个周期中。数据还将包括五年的Core Swan研究 关于更年期特征的数据(出血模式、血管运动症状、 激素水平)和相关的心理生物学因素。回归技术 将被用来模拟更年期特征、睡眠、 以及相关的心理生物学因素。匹兹堡站点将进行培训研究 人员在使用睡眠监测设备时，将负责 对所有睡眠数据进行处理、评分和存档。所有睡眠研究数据，如 以及来自Core Swan研究的相关数据，将由 密歇根的网站。芝加哥和加州大学戴维斯分校的PI将共同主持睡眠研究 督导委员会。

DESCRIPTION: (provided by applicant) This interactive Research Project Grant (IRPG) will characterize the relationship between menopausal characteristics and sleep in a sample of 430 women: 200 Caucasian, 150 African-American, and 80 Chinese. Although sleep disruptions, insomnia and the incidence of sleep disordered breathing increase in mid-life women, little is known about the relationship between menopause and sleep. The impact of vasomotor symptoms and hormone replacement therapy on sleep suggests that the sleep-menopause relationship is not merely a function of age. A greater understanding of the causes of sleep disturbances in mid-life women is important, given the impact of sleep on mental and physical health. Sleep disturbances are associated with a host of negative health outcomes including losses in productivity and quality of life, psychiatric morbidity, immunosuppression, and increased vulnerability to illness and disease. The study aims of this IRPG are to: 1) characterize sleep disturbances in a large, multi-ethnic sample of mid-life women; 2) characterize relationships among menopausal characteristics and sleep disturbances; 3) evaluate the influence of relevant psychobiological factors on the sleep-menopause relationship; and 4) establish baseline data for a future longitudinal study. Four of seven study sites from the ongoing Study of Women s Health Across the Nation (SWAN) will collaborate to recruit a sample of pre- and peri-menopausal women from the SWAN cohort. Once enrolled in the Sleep Study, participants will begin the protocol at the start of a new menstrual cycle. Ambulatory polysomnography will be conducted in participants homes during days 1-3 of the protocol. Sleep diary, actigraphy, and event monitor recordings of vasomotor symptom data will be collected throughout the cycle. Data will also include five years of Core SWAN study data on menopausal characteristics (bleeding patterns, vasomotor symptoms, hormone levels) and related psychobiological factors. Regression techniques will be used to model relationships among menopausal characteristics, sleep, and related psychobiological factors. The Pittsburgh site will train study personnel in the use of sleep monitoring equipment and will be responsible for processing, scoring, and archiving all sleep data. All sleep study data, as well as relevant data from the Core SWAN study, will be merged and analyzed by the Michigan site. The Chicago and UC Davis PIs will co-chair the Sleep Study Steering Committee.