Epidemiology studies

该项目的目标是将加州大学戴维斯分校超级基金实验室迄今开发的暴露和结果生物标志物应用于可能暴露于有害物质的人群，以便提供暴露和健康结果的实验室/生物评估。该项目在加州大学戴维斯分校超级基金的这一阶段是及时的，该项目将在此开发的测定技术应用于现实生活中的人类环境，以提供有关此类方法可行性的实用信息以及有关人类暴露于超级基金关注的有毒物质的可能性的客观数据，以及此类暴露与人类不良健康影响的关系。具体而言，该项目的目标是：a）使用母亲每月的尿样，评估对人类健康的不利影响，特别是对神经和神经行为的影响，或对农场工人社区儿童接触有机磷的影响（包括农场工人和非农场工人）及其子女评估（OP）代谢物，如OP的葡萄糖醛酸苷; B）确定接触的普遍程度，并将免疫测定法的结果与气相色谱法的结果进行比较; d）第二阶段评估可能接触环境内分泌干扰物和其他可能有害的接触与有害生殖和其他环境因素之间的关系，在邻近当地超级基金场址的居民社区中对人类健康的影响;以及e）比较有可能和不太可能接触的家庭成员的机会性血液样本中的甲状腺激素水平和甲状腺疾病的治疗。该项目还将提供流行病学实地研究，以审查接触有害环境物质在增加对人类健康产生不利影响的风险方面的作用。

The goal of this project is to apply biomarkers of exposures and outcomes that have been developed thus far in the UC Davis Superfund laboratories to human populations with likely exposures to hazardous substances so as to provide laboratory/biologic assessment of exposures and health outcomes. This project is timely at this stage of the UC Davis Superfund effort in taking assay techniques that have been developed here into a real-lifer human setting to provide both practical information about the feasibility of such approaches as well as objective data about the likelihood of exposure of human populations to toxicants of interest to Superfund and the relation of such exposures ti adverse health effects in humans. Specifically the aims of this project are: a) evaluate the adverse human health effects, particularly neurologic and neurobehavioral effects, or organophosphate (OP) exposure in children in a farmworker community using monthly urine samples from mothers (including farmworkers and non-farmworkers) and their children to assess (OP) metabolites, such as glucuronides of Ops; b) to determine the prevalence of exposure and compare immunoassay to gas chromatography results; c) to evaluate the likely routes of exposure; d) to evaluate the relation of potential exposure to environmental endocrine disruptors and other potentially hazardous exposures to adverse reproductive and other human health effects in a residential community adjacent to a local Superfund site; and e) to compare thyroid hormone levels in opportunistic blood samples and treatment for thyroid disorders of household members who are likely and those who are unlikely to be exposed. This project will also provide epidemiologic field studies to examine the role of exposure to hazardous environmental substances in increasing the risk of adverse human health effects.