Epidemiology and Biostatistics

流行病学和生物统计学核心（EBC）的目的是为SCOR中的所有项目提供以下信息： 研究设计和数据分析方面的指导和协作。EBC将发挥核心作用， 将动物研究、人口研究（流行病学）和 生物医学/临床和实验/临床研究。EBC有两个总体目标：1） 促进项目的目标，加强跨学科研究和翻译的整合， 基础卫生科学和流行病学及临床调查成为实用的诊断工具， 在临床和社区人群中预防和治疗肌肉骨骼疾病;以及2） 为所有四个项目和试点项目提供有关研究设计、数据 管理和数据分析。EBC将在假设制定方面提供建议和合作， 实验和研究设计，比较组的选择，入选和排除标准，随机 两项临床试验参与者的分配、标准数据收集工具和方法 （包括数据收集的质量控制措施）、潜在混杂因素的选择和标准 变量、适当的统计分析技术和数据分析结果的解释。的 EBC的调查人员将与项目调查人员合作，开发、实施、分析和撰写 该SCOR项目的结果。EBC有四个主要目标：1）提供高质量的 与项目领导人密切合作，在SCOR研究设计中进行磋商和合作 和调查人员设计研究问题和数据收集工具， 准确分析数据和适当选择研究组，以提供有效的设计; 2） 在开发和实施数据管理系统方面提供援助，以促进有效、高效 数据的安全管理和分析; 3）提供适当和及时的定量统计 对所有项目进行分析;以及4）对统计结果提供适当的，有见地的解释 为项目提供分析。EBC的联合董事拥有数十年的经验， 在研究设计、数据收集和统计分析方面建立了观察性和 实验（特别是临床试验）研究，并有充分的能力为该核心共同做出决定。 他们还拥有与来自许多不同学科的研究人员合作的丰富经验， 致力于跨学科合作并提供明智的建议。

The purpose of the Epidemiology and Biostatistics Core (EBC) is to provide all projects in this SCOR with guidance and collaboration regarding study design and data analyses. The EBC will play a central role in integrating the basic science of the animal study, the human population study (epidemiology), and the biomedical/clinical and experimental/clinical investigations. The EBC has two overarching goals: 1) facilitating the goals of the projects and enhancing integration of inter-disciplinary research and translation of basic health science and epidemiologic and clinical investigation into practical tools for the diagnosis, prevention and treatment of musculoskeletal disease in clinical and community-based populations; and 2) providing guidance and collaboration for all four projects and pilot projects regarding study design, data management and data analyses. The EBC will provide advice and collaboration in hypothesis formulation, experimental and study design, selection of comparison groups, inclusion and exclusion criteria, random assignment of participants in the two clinical trials, standard data collection instruments and methods (including quality control measures for data collection), selection of and criteria for potential confounding variables, appropriate statistical analytic techniques and interpretation of results of data analyses. The investigators in the EBC will work with the project investigators to develop, implement, analyze and write up the results of the projects of this SCOR. The EBC has four primary aims: 1) to provide high quality consultation and collaboration in the design of the studies of this SCOR, working closely with project leaders and investigators to design research questions and data collection tools that will facilitate appropriate and accurate analyses of data and appropriate selection of study groups to provide efficient designs; 2) to provide assistance in developing and implementing data management systems to facilitate effective, efficient and secure management and analyses of data; 3) to provide appropriate and timely quantitative statistical analyses for all projects; and 4) to provide appropriate, insightful interpretation of the results of statistical analyses provided to the projects. The Co-Directors of the EBC have decades of experience and well- established expertise in study design, data collection, and statistical analyses for both observational and experimental (specifically, clinical trial) studies and are well-equipped to make decisions jointly for this Core. They also have extensive experience in collaborating with investigators from many different disciplines and are dedicated to inter-disciplinary collaboration and providing well-informed advice.