Epidemiology studies

该项目的目标是将加州大学戴维斯分校超级基金实验室迄今开发的暴露和后果生物标记物应用于可能暴露于危险物质的人群，以便提供暴露和健康后果的实验室/生物评估。在加州大学戴维斯分校超级基金努力的这个阶段，该项目适时地将这里开发的化验技术应用到真实的人体环境中，以提供有关此类方法的可行性的实用信息，以及关于人类暴露于Superfund感兴趣的毒物的可能性以及此类暴露与人类不良健康影响的关系的客观数据。该项目的具体目标是：a)使用母亲(包括农场工人和非农场工人)及其子女每月的尿样评估(OP)代谢物(OP)代谢物，如OP的葡萄糖醛酸化物，以评估对人类健康的不利影响，特别是神经和神经行为影响，或有机磷(OP)在农场工人社区儿童中的暴露；b)确定暴露的流行率，并将免疫分析结果与气相色谱结果进行比较；c)评估可能的暴露途径；d)评估与环境内分泌干扰物的潜在暴露和当地超级基金附近的居民区其他潜在危险暴露对生殖和其他人类健康不利影响的关系；以及e)比较机会性血液样本中的甲状腺激素水平以及可能接触和不太可能接触的家庭成员对甲状腺疾病的治疗。该项目还将提供流行病学实地研究，以审查暴露于危险环境物质在增加对人类健康不利影响的风险方面的作用。

The goal of this project is to apply biomarkers of exposures and outcomes that have been developed thus far in the UC Davis Superfund laboratories to human populations with likely exposures to hazardous substances so as to provide laboratory/biologic assessment of exposures and health outcomes. This project is timely at this stage of the UC Davis Superfund effort in taking assay techniques that have been developed here into a real-lifer human setting to provide both practical information about the feasibility of such approaches as well as objective data about the likelihood of exposure of human populations to toxicants of interest to Superfund and the relation of such exposures ti adverse health effects in humans. Specifically the aims of this project are: a) evaluate the adverse human health effects, particularly neurologic and neurobehavioral effects, or organophosphate (OP) exposure in children in a farmworker community using monthly urine samples from mothers (including farmworkers and non-farmworkers) and their children to assess (OP) metabolites, such as glucuronides of Ops; b) to determine the prevalence of exposure and compare immunoassay to gas chromatography results; c) to evaluate the likely routes of exposure; d) to evaluate the relation of potential exposure to environmental endocrine disruptors and other potentially hazardous exposures to adverse reproductive and other human health effects in a residential community adjacent to a local Superfund site; and e) to compare thyroid hormone levels in opportunistic blood samples and treatment for thyroid disorders of household members who are likely and those who are unlikely to be exposed. This project will also provide epidemiologic field studies to examine the role of exposure to hazardous environmental substances in increasing the risk of adverse human health effects.