Epidemiologic Studies

流行病学研究项目通过评估生理功能障碍来评估加州萨克拉门托超级基金所在地附近居民暴露在环境污染物中对人类健康的影响。具体地说，将确定居住在萨克拉门托超级基金所在地顺风向或地下水羽流中的妇女的生殖和其他与激素有关的健康影响。这些对健康影响的比率将与附近类似的非暴露妇女样本中的比率进行比较，这些比率也将与暴露的可能性有关。除了采访居住在这些地区和比较地区的妇女外，我们还将使用加州大学戴维斯分校实验室开发的暴露和健康结果的血清和尿液生物标记物。到目前为止，该项目已在三个研究地区筛选了850多名符合条件的妇女，并对这三个地区350多名符合条件的妇女进行了采访和化验。这三个研究领域在一些社会人口指标以及一般社区和妇女的健康问题上似乎具有可比性(前五个领域中没有一个分别包括超级基金网站或内分泌/生殖问题)。此外，我们没有观察到三个研究地区的甲状腺激素水平如预期般有显著差异，因为可能影响甲状腺功能的相关接触已于1996年结束，预计不会对甲状腺产生长期的不良影响。到目前为止，我们在测试的任何样本(n=250)中都没有检测到环境雌激素的证据。观察到的生殖健康影响的一些差异是有启发意义的，但需要进一步的数据分析，以确定在可能的暴露时间内可能发生的健康影响的任何差异。流行病学技术在该项目中的应用不仅将促进生物标志物在暴露人群中的人类应用和环境污染物暴露对人类健康影响的评估，而且还将阐明宿主和生活方式因素对这些影响的修正。反过来，该项目将通过为进一步开发领域提供流行病学专业知识，为其他项目做出贡献。 UCD实验室开发的技术在未来的应用。在这项工作中，该项目将高度依赖各种分析项目，如命运和运输项目和生殖生物标记项目，以及统计核心，以评估居住在下风向或超级基金场地地下水羽流中对内分泌干扰物的暴露，评估可能的暴露途径，并评估这种暴露与生殖和其他内分泌健康不良影响的关系。

The Epidemiologic Studies project provides evaluation of human health effects associated with exposure to environmental contaminants in residents adjacent to a Superfund site in Sacramento, California by evaluating physiologic dysfunction. Specifically, reproductive and other hormone-related health effects will be ascertained in women residing downwind or in the groundwater plume of the Sacramento Superfund site. These rates of health effects will be compared to those in a similar, non-exposed nearby sample of women, and these rates will also be related to likelihood of exposure. In addition to interviewing women residing in these areas and in a comparison area, we will use serum and urine biomarkers of exposure and of health outcomes that have been developed in UC Davis laboratories. Thus far, this project has screened for eligibility over 850 women in the three study areas and has interviewed and assayed blood and urine from over 350 eligible women in the three areas. The three study areas appear comparable on a number of sociodemographic indicators, as well as on general community and women's health concerns (none of the top 5 of which include the Superfund site or endocrine/reproductive concerns, respectively). Further, we have observed no notable differences in thyroid hormone levels among the three study areas, as expected, since the relevant exposure that might have affected thyroid function ended in 1996, and no prolonged adverse effect on the thyroid would be expected. We have detected no evidence of environmental estrogens in any of the samples tested thus far (n=250). Some observed differences in reproductive health effects are suggestive, but further analyses with additional data are required to determine any differences in health effects that might have occurred during the times of likely exposure. Applications of epidemiologic techniques in this project will not only facilitate applications of the biomarkers in humans in the exposed population and assessment of the relation of exposure to environmental contaminants to human health effects, but will also illuminate modification of these effects by host and lifestyle factors. In turn, this project will contribute to the other projects by providing epidemiologic expertise for developing further field applications of techniques developed in the UCD laboratories in the future. In this effort, this project will be highly dependent on the various analytic projects, such as the Fate and Transport Project and Reproductive Biomarkers Project, as well as the Statistical Core to evaluate exposures to endocrine disrupters as a result of residing downwind or in the groundwater plume of a Superfund site, to assess the likely routes of exposure, and to assess the relation of such exposures to adverse reproductive and other endocrine health effects.