HIGH RESOLUTION BOLD VENOGRAPHIC IMAGING
高分辨率大胆静脉造影成像
基本信息
- 批准号:6537615
- 负责人:
- 金额:$ 34.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-06-16 至 2004-05-31
- 项目状态:已结题
- 来源:
- 关键词:bioimaging /biomedical imaging blood volume brain circulation brain disorder diagnosis brain imaging /visualization /scanning clinical research contrast media diagnosis quality /standard functional magnetic resonance imaging hemodynamics human subject method development neurophysiology oxygen oxygen transport oxyhemoglobin venography
项目摘要
DESCRIPTION (Verbatim from the Applicant's Abstract): A new venographic imaging method has been developed to probe brain function. The method relies on the
changes induced in the MR signal in venous blood caused by the blood
oxygenation level dependent (BOLD) effect from the presence of
de-oxyhemoglobin. These changes cause a signal loss in the MR images due to the
cancellation of venous blood with surrounding brain parenchyma. When this
signal loss is examined as a function of echo time it reveals a unique
signature, a non-exponential decay, indicative of the state of oxygen
saturation and venous blood volume in the tissue. In this proposal, we plan to
use a high resolution 3D version of this BOLD venographic (HRBV) method to
cover a large region of interest in the brain. Specifically, we wish to
understand the roles of intravascular and extravascular effects in causing this
signal loss as a function of vessel size, oxygen saturation and field strength.
Given this knowledge, we will attempt to predict both venous oxygen saturation
and venous blood volume. This capability will be used under a number of
physiologically challenged states in the brain using oxygen, and diamox. It is
expected that a robust 3D methodology will be developed and validated to make
this approach generally viable for clinical utility in the future. As part of
this goal, we will revisit the quantification of oxygen saturation and blood
volume measurements using a T1 reducing contrast agent. This will lead to
higher quality images and improved accuracy and precision. Finally, we will
test a new approach to functional brain imaging which offers the advantage of
having a reduced sensitivity to field distortion and its associated signal loss
when very long echo times are used. Today, refined techniques exist to handle
many of the key experimental issues needed to accomplish these goals. The
success of this research may offer a better means to evaluate brain function in
fMRI experiments, to diagnose occult venous lesions, to study tumors and other
vascular related diseases.
描述(申请人摘要中的逐字引用):一种新的静脉造影成像 已经开发出一种方法来探测大脑功能。该方法依赖于
由血液引起的静脉血中MR信号的变化
氧合水平依赖性(BOLD)效应
脱氧血红蛋白这些变化导致MR图像中的信号损失,
静脉血与周围脑实质的抵消。当这个
信号损失被检查为回波时间的函数,它揭示了一个独特的
信号,非指数衰减,指示氧的状态
组织中的饱和度和静脉血容量。在这份提案中,我们计划
使用这种BOLD静脉造影(HRBV)方法的高分辨率3D版本,
覆盖了大脑中很大一部分区域具体而言,我们希望
了解血管内和血管外效应在导致这种情况中的作用,
作为血管尺寸、氧饱和度和场强的函数的信号损失。
有了这些知识,我们将尝试预测静脉血氧饱和度
和静脉血容量。这一能力将在一些
大脑中的生理挑战状态,使用氧气和二乙酰唑胺。是
预计将开发和验证一种强大的3D方法,
这种方法在将来的临床应用中通常是可行的。的一部分
为了实现这一目标,我们将重新审视血氧饱和度和血液的量化。
使用T1降低造影剂进行体积测量。这将导致
更高质量的图像和更高的准确性和精度。最后我们将
测试一种新的脑功能成像方法,
对场失真及其相关的信号损失具有降低的灵敏度
当使用非常长的回波时间时。今天,先进的技术可以处理
实现这些目标所需的许多关键实验问题。的
这项研究的成功可能会提供一种更好的方法来评估大脑功能,
功能磁共振成像实验,诊断隐匿性静脉病变,研究肿瘤和其他
血管相关疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ewart Mark Haacke其他文献
Strategically acquired gradient echo (STAGE)-derived MR angiography might be a superior alternative method to time-of-flight MR angiography in visualization of leptomeningeal collaterals
在软脑膜侧枝可视化方面,策略性梯度回波 (STAGE) 衍生的 MR 血管造影可能是飞行时间 MR 血管造影的更好替代方法
- DOI:
10.1007/s00330-020-06840-7 - 发表时间:
2020-04 - 期刊:
- 影响因子:5.9
- 作者:
Ruowei Tang;Qingqing Zhang;Yongsheng Chen;Song Liu;Ewart Mark Haacke;Bin-ge Chang;Shuang Xia - 通讯作者:
Shuang Xia
Ewart Mark Haacke的其他文献
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{{ truncateString('Ewart Mark Haacke', 18)}}的其他基金
ACQUIRING A 3T PRISMA FOR NEUROSCIENCE RESEARCH AT WSU
为 WSU 的神经科学研究购买 3T PRISMA
- 批准号:
10430689 - 财政年份:2022
- 资助金额:
$ 34.45万 - 项目类别:
Automatic Quantification and Labeling of Cerebral Microbleeds, Oxygen Saturation and Sources of Abnormal Susceptibility
脑微出血、氧饱和度和异常易感性来源的自动定量和标记
- 批准号:
10026456 - 财政年份:2019
- 资助金额:
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Assessing Brain Tissue Viability after TBI: A Susceptibility Mapping Approach
评估 TBI 后脑组织的活力:敏感性图谱方法
- 批准号:
8970279 - 财政年份:2015
- 资助金额:
$ 34.45万 - 项目类别:
Development of flow and vascular quantification software for the assessment of MR
开发用于评估 MR 的流量和血管量化软件
- 批准号:
8369059 - 财政年份:2012
- 资助金额:
$ 34.45万 - 项目类别:
Development of flow and vascular quantification software for the assessment of MR
开发用于评估 MR 的流量和血管量化软件
- 批准号:
8601361 - 财政年份:2012
- 资助金额:
$ 34.45万 - 项目类别:
Development of flow and vascular quantification software for the assessment of MR
开发用于评估 MR 的流量和血管量化软件
- 批准号:
8626440 - 财政年份:2012
- 资助金额:
$ 34.45万 - 项目类别:
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