Evaluation of New Imaging Methodologies at 7T

描述(由申请人提供)：申请资金购买30厘米口径，主动屏蔽7.0T成像(MRI)和光谱学(MRS)布鲁克/西门子动物研究系统。韦恩州立大学医学院迫切需要一种最先进的高场动物系统。现有的两个布鲁克动物研究系统，一个4.7T 30厘米口径和一个11JT小口径系统。第一个单元不提供必要的信噪比，而第二个单元通常不被配置为执行成像。对于韦恩州立大学(WSU)正在进行的众多研究项目来说，对更高的信噪比和分辨率的需求至关重要。4.7T动物系统是我们用户便利设施的一部分，它的使用率很高。此外，我们拥有全身4T Bruker/西门子系统，并在全国各地增加了7T人体系统，该系统将允许将我们的研究直接转化为人体研究，尽管在我们自己的设施之外是一个主要优势。这将使我们的研究对一般的成像研究界更有价值。一个由七个主要用户组成的小组将需要7.0T系统上的大部分机器时间，但至少还有其他七个项目正在寻求NIH的资金。这些项目的重点是眼睛的高分辨率成像、血氧饱和度成像、肿瘤成像、光谱学、血管生成、血管成像和创伤。这些项目涉及糖尿病、血管疾病和精神疾病等重要领域。在这个动物系统上开发和应用的许多方法预计将产生重要的临床影响。所有这些项目都将从拟议的收购中受益匪浅。

DESCRIPTION (provided by applicant): Funds for the acquisition of a 30 cm bore, actively shielded 7.0 T imaging (MRI) and spectroscopy (MRS) Bruker/Siemens animal research system are requested. There is a strong need for a state-of-the-art high field animal system at Wayne State University School of Medicine. There are two existing Bruker animal research systems, a 4.7T 30cm bore and an 11JT small bore system. The first unit does not provide the necessary signal-to-noise while the second is not routinely configured to perform imaging. The need for higher signal-to-noise ratio and resolution is critical for the numerous research projects underway at Wayne State University (WSU). The 4.7T animal system is part of our user's facilty and its usage is high. In addition, we have a whole body 4T Bruker/Siemens system and with the addition of 7T human systems around the country having a system that will allow translation of our research directly to human studies even though outside our own facility is a major advantage. This will make our research more valuable to the imaging research community in general. A group of seven major users will require the majority of machine time on the 7.0 T system but there are at least seven other projects already underway seeking NIH funding. These projects focus on high resolution imaging of the eye, oxygen saturation imaging, tumor imaging, spectroscopy, angiogenesis, vascular imaging and trauma. These projects relate to important areas such as diabetes, vascular disease and psychiatric disorders. Many of the approaches developed and applied on this animal system are expected to have important clinical impact. All of these projects will substantially benefit from the proposed acquisition.