Evaluation of New Imaging Methodologies at 7T

7T 新成像方法的评估

• 批准号: 7125717
• 负责人: Ewart Mark Haacke
• 金额: $ 199万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125717
• 关键词: Adult; Age; Anatomy; Animal Experimentation; Animal Model; Animals; Area; Arts; Biomedical Research; Blood Vessels; Brain; Clinical; Communities; Country; Development; Diabetes Mellitus; Evaluation; Eye; Funding; Funding Applicant; Human; Image; Invasive; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mental disorders; Methodology; Mus; Newborn Infant; Noise; Oxygen; Range; Rattus; Research; Research Project Grants; Resolution; Retinal Neoplasms; Signal Transduction; Spectrum Analysis; System; Technology; Time; Tissues; Translational Research; Translations; Trauma; United States National Institutes of Health; Universities; Vascular Diseases; angiogenesis; human study; medical schools; systems research; tumor

DESCRIPTION (provided by applicant): Funds for the acquisition of a 30 cm bore, actively shielded 7.0 T imaging (MRI) and spectroscopy (MRS) Bruker/Siemens animal research system are requested. There is a strong need for a state-of-the-art high field animal system at Wayne State University School of Medicine. There are two existing Bruker animal research systems, a 4.7T 30cm bore and an 11JT small bore system. The first unit does not provide the necessary signal-to-noise while the second is not routinely configured to perform imaging. The need for higher signal-to-noise ratio and resolution is critical for the numerous research projects underway at Wayne State University (WSU). The 4.7T animal system is part of our user's facilty and its usage is high. In addition, we have a whole body 4T Bruker/Siemens system and with the addition of 7T human systems around the country having a system that will allow translation of our research directly to human studies even though outside our own facility is a major advantage. This will make our research more valuable to the imaging research community in general. A group of seven major users will require the majority of machine time on the 7.0 T system but there are at least seven other projects already underway seeking NIH funding. These projects focus on high resolution imaging of the eye, oxygen saturation imaging, tumor imaging, spectroscopy, angiogenesis, vascular imaging and trauma. These projects relate to important areas such as diabetes, vascular disease and psychiatric disorders. Many of the approaches developed and applied on this animal system are expected to have important clinical impact. All of these projects will substantially benefit from the proposed acquisition.

描述（由申请人提供）：申请资金用于购买30 cm孔径、主动屏蔽7.0 T成像（MRI）和光谱（MRS）Bruker/Siemens动物研究系统。韦恩州立大学医学院迫切需要一个最先进的高场动物系统。布鲁克现有两个动物研究系统，一个4.7T 30 cm内径系统和一个11 JT小口径系统。第一个单元不提供必要的信噪比，而第二个单元通常不配置为执行成像。对于韦恩州立大学（WSU）正在进行的众多研究项目来说，对更高信噪比和分辨率的需求至关重要。4.7T动物系统是我们用户设施的一部分，使用率很高。此外，我们还拥有一个全身4 T布鲁克/西门子系统，并在全国各地增加了7 T人体系统，该系统可以将我们的研究直接转化为人体研究，尽管在我们自己的设施之外也是一个主要优势。这将使我们的研究对成像研究界更有价值。一组七个主要用户将需要在7.0 T系统上的大部分机器时间，但至少有七个其他项目已经在寻求NIH的资助。这些项目的重点是眼睛的高分辨率成像、氧饱和度成像、肿瘤成像、光谱学、血管生成、血管成像和创伤。这些项目涉及糖尿病、血管疾病和精神疾病等重要领域。许多在这种动物系统上开发和应用的方法预计将产生重要的临床影响。所有这些项目都将从拟议收购中受益。