ACQUIRING A 3T PRISMA FOR NEUROSCIENCE RESEARCH AT WSU

项目概要/摘要：本申请建议合作购买西门子3T PRISMA 用于人类研究的150 mT/m梯度扫描仪，位于底特律的韦恩州立大学（WSU）， 密歇根PRISMA将取代已有12年历史的西门子VERIO，后者已经达到了使用寿命的终点。 制造商将不再支持以前的软件版本VB19。PRISMA是 3T成像的世界标准。在过去的三十年里，WSU MR成像社区为 医学成像技术，包括MR序列设计和软件开发，其中一些已经 全世界采用。华盛顿州立大学的研究人员正在研究大脑灰质和白色组织的微血管， 神经系统疾病（多发性硬化症和帕金森病）。其他NIH资助的研究 专注于了解胎儿/产后发育;大脑和大脑之间的神经相关性， 行为/认知;障碍中的回路/网络功能障碍;以及压力/创伤和物质的影响 对大脑功能的影响。在过去的五年里，华盛顿州立大学的磁共振成像社区和基地的校外资助， 研究成长了。现在，四所学校和学院的十四（14）名NIH资助的研究人员正在进行研究。 积极从事人体成像研究。提供了数据协调计划。2016 - 2020年，外部 用于神经科学相关研究的资金从400万美元增加到700万美元。不仅VERIO接近容量， 即使在短期内，由于其过时的能力，它也无法容纳新的高端MR项目。 自2009年安装以来，西门子高场3 T成像技术不断进步。现在，它包括多个- 通道接收线圈系统、多通道发射和更高梯度。150mT/m超强梯度 PRISMA的使用将极大地提高MR成像的空间和时间分辨率， 更精细的解剖结构和增强脑微结构的组织表征。PRISMA提供 新的软件，序列，快速成像方法，以及各种技术成像的进步， 我们的VERIO立即，PRISMA将：（a）支持11个主要用户和3个次要用户，（B）加速NIH> 2800万美元 和其他赞助的研究，并使未来的奖项，（c）位置WSU继续推动创新的MR 成像技术，和（d）支持区域MR社区。PRISMA将是其唯一的扫描仪。 在密歇根州东部。WSU承诺支持购买3T PRISMA（120万美元的成本分摊） 并将每年为MR核心研究设施的核心基础设施和缺口资金提供高达42.5万美元的资金 （MRRF）。除了研究之外，PRISMA还将用于研究生和研究生培训。MRRF 主管和PI E。马克·哈克在成像领域设立了一个双头衔项目，并帮助创建了一个部门， 生物医学工程（BME）在医学院。PRISMA将取代VERIO（将 作为所有成像的中心。WSU未来的神经科学研究需要先进的成像技术 PRISMA将提高18项NIH研究的生产率和未来工作的整体竞争力。

PROJECT SUMMARY/ABSTRACT: This application proposes the collaborative purchase of a Siemens 3T PRISMA scanner with 150mT/m gradients for human research, sited at Wayne State University (WSU) in Detroit, Michigan. The PRISMA will replace a 12-year old Siemens VERIO, which has reached the end of its useful lifetime and will no longer be supported by the manufacturer past software version VB19. The PRISMA is the world standard for 3T imaging. Over the last three decades, the WSU MR imaging community has contributed medical imaging technology including MR sequence design and software development some of which has been adopted worldwide. Researchers at WSU are studying the microvasculature of grey and white matter tissue in neurological conditions and disorders (multiple sclerosis and Parkinson’s disease). Other NIH-funded research is focused on understanding fetal/postnatal development; neural correlates between the brain and behavior/cognition; dysfunctions of circuits/networks in disorders; and the impact of stress/trauma and substance use on brain function. In the last five years, WSU’s MR imaging community—and base of extramurally-funded research—has grown. Fourteen (14) NIH-funded investigators across four Schools and Colleges are now actively engaged in human imaging studies. A data harmonization plan is provided. Between 2016-2020, external funding for neuroscience-related research increased from $4M to $7M. Not only is the VERIO near capacity, but even in the short-term, it is unable to accommodate new high-end MR projects due to its outdated capabilities. Since its installation in 2009, Siemens high field 3T imaging technology has advanced. It now includes multi- channel receive coil systems, multi-channel transmit, and higher gradients. The 150mT/m ultra-strong gradients of the PRISMA will dramatically improve the spatial and temporal resolution of MR imaging—critical for detecting finer anatomical structures and enhancing tissue characterization of brain microstructure. The PRISMA offers new software, sequences, fast imaging methods, and a variety of technical imaging advances not available on our VERIO. Immediately, the PRISMA will: (a) support 11 major and 3 minor users, (b) accelerate >$28M in NIH and other sponsored research and enable future awards, (c) position WSU to continue to drive innovative MR imaging techniques, and (d) support the regional MR community. The PRISMA will be the only scanner of its kind in Eastern Michigan. WSU is committed to support the purchasing of the 3T PRISMA ($1.2M cost share) and will provide up to $425K/annually for core infrastructure and gap funding for the MR Core Research Facility (MRRF). In addition to research, the PRISMA will be used for graduate and post-graduate training. MRRF Director and PI E. Mark Haacke instituted a dual title program in imaging and helped create a division of Biomedical Engineering (BME) within the School of Medicine. The PRISMA will replace the VERIO (which will be decommissioned) as the hub for all imaging. WSU’s future neuroscience research requires advanced imaging capabilities; the PRISMA will improve productivity of 18 NIH studies and overall competitiveness for future work.