ACQUIRING A 3T PRISMA FOR NEUROSCIENCE RESEARCH AT WSU

项目摘要/摘要：本申请提出协同采购西门子3T棱镜 底特律韦恩州立大学(WSU)人体研究用150mT/m梯度扫描仪， 密歇根州。Prisma将取代已有12年历史的西门子Verio，后者已达到其使用寿命 终身有效，制造商将不再支持VB19以前的软件版本。棱柱体是 3T成像的世界标准。在过去的三十年里，威斯康星州立大学磁共振成像界做出了贡献 医学成像技术，包括磁共振序列设计和软件开发，其中一些已经 在世界范围内被采用。华盛顿州立大学的研究人员正在研究大脑灰质和白质组织的微血管系统。 神经系统疾病和障碍(多发性硬化症和帕金森氏病)。美国国立卫生研究院资助的其他研究 专注于了解胎儿/出生后的发育；大脑和大脑之间的神经关联 行为/认知；障碍中的电路/网络功能障碍；以及应激/创伤和物质的影响 对大脑功能的影响。在过去的五年里，威斯康星州立大学的磁共振成像社区-也是外部资助的基地 研究-增长了。来自四所学校和学院的十四(14)名由NIH资助的调查人员现在 积极从事人体影像研究。提供了数据协调计划。2016-2020年间，外部 用于神经科学相关研究的资金从400万美元增至700万美元。Verio不仅接近满载，而且 即使在短期内，由于其过时的能力，它也无法容纳新的高端MR项目。 自2009年安装以来，西门子高场3T成像技术取得了进步。它现在包括多个 通道接收线圈系统、多通道传输和更高的梯度。150mT/m超强梯度 将极大地提高磁共振成像的空间和时间分辨率--这对检测至关重要 更精细的解剖结构和增强脑微结构的组织表征。Prisma提供 上没有的新软件、序列、快速成像方法和各种先进的成像技术 我们的维里奥。现在，PRISMA将：(A)支持11个主要用户和3个次要用户，(B)在NIH加速&>2800万美元 和其他赞助的研究，并支持未来的奖项，(C)定位西澳州立大学继续推动创新的MR (D)支持区域磁共振社区。Prisma将成为其唯一的扫描仪 密歇根州东部的一种。WSU承诺支持购买3T Prisma(120万美元的成本份额) 并将每年为核心基础设施提供高达42.5万美元的资金，并为MR核心研究基金提供缺口资金 (MRRF)。除了研究，PRISMA还将用于研究生和研究生培训。MRRF 导演和Pi E.Mark Haacke在成像方面建立了一个双重头衔计划，并帮助创建了一个部门 医学院内的生物医学工程(BME)。Prisma将取代Verio(将 退役)作为所有成像的中心。华盛顿州立大学未来的神经科学研究需要先进的成像技术 能力；PRISMA将提高NIH 18项研究的生产率和未来工作的整体竞争力。

PROJECT SUMMARY/ABSTRACT: This application proposes the collaborative purchase of a Siemens 3T PRISMA scanner with 150mT/m gradients for human research, sited at Wayne State University (WSU) in Detroit, Michigan. The PRISMA will replace a 12-year old Siemens VERIO, which has reached the end of its useful lifetime and will no longer be supported by the manufacturer past software version VB19. The PRISMA is the world standard for 3T imaging. Over the last three decades, the WSU MR imaging community has contributed medical imaging technology including MR sequence design and software development some of which has been adopted worldwide. Researchers at WSU are studying the microvasculature of grey and white matter tissue in neurological conditions and disorders (multiple sclerosis and Parkinson’s disease). Other NIH-funded research is focused on understanding fetal/postnatal development; neural correlates between the brain and behavior/cognition; dysfunctions of circuits/networks in disorders; and the impact of stress/trauma and substance use on brain function. In the last five years, WSU’s MR imaging community—and base of extramurally-funded research—has grown. Fourteen (14) NIH-funded investigators across four Schools and Colleges are now actively engaged in human imaging studies. A data harmonization plan is provided. Between 2016-2020, external funding for neuroscience-related research increased from $4M to $7M. Not only is the VERIO near capacity, but even in the short-term, it is unable to accommodate new high-end MR projects due to its outdated capabilities. Since its installation in 2009, Siemens high field 3T imaging technology has advanced. It now includes multi- channel receive coil systems, multi-channel transmit, and higher gradients. The 150mT/m ultra-strong gradients of the PRISMA will dramatically improve the spatial and temporal resolution of MR imaging—critical for detecting finer anatomical structures and enhancing tissue characterization of brain microstructure. The PRISMA offers new software, sequences, fast imaging methods, and a variety of technical imaging advances not available on our VERIO. Immediately, the PRISMA will: (a) support 11 major and 3 minor users, (b) accelerate >$28M in NIH and other sponsored research and enable future awards, (c) position WSU to continue to drive innovative MR imaging techniques, and (d) support the regional MR community. The PRISMA will be the only scanner of its kind in Eastern Michigan. WSU is committed to support the purchasing of the 3T PRISMA ($1.2M cost share) and will provide up to $425K/annually for core infrastructure and gap funding for the MR Core Research Facility (MRRF). In addition to research, the PRISMA will be used for graduate and post-graduate training. MRRF Director and PI E. Mark Haacke instituted a dual title program in imaging and helped create a division of Biomedical Engineering (BME) within the School of Medicine. The PRISMA will replace the VERIO (which will be decommissioned) as the hub for all imaging. WSU’s future neuroscience research requires advanced imaging capabilities; the PRISMA will improve productivity of 18 NIH studies and overall competitiveness for future work.