Susceptibility Weighted Imaging (SWI)

描述(申请人提供)：磁化率加权成像(SWI)已成为诊断大脑疾病的重要新工具。它被用来研究大脑的血管系统，检测大脑中的铁和可视化微小出血。该方法依赖于组织之间敏感性的变化，从而导致组织之间的相位差的引入和信号损失。它已被证明是更好地诊断创伤、中风和肿瘤以及检测大脑功能变化的强大手段。我们希望继续开发SWI以：a)通过减少相位处理伪影使其在临床上更具可行性；b)通过创建人体组织的敏感度图来评估敏感性本身；c)通过同时收集MRA和SWI数据来研究其作为一种新的MR血管成像方法的作用；以及d)将其采集时间加快到全脑覆盖的5分钟以内，而不受任何平行成像增益因素的影响。这些问题的解决不仅是对目前使用的SWI的进步，而且也为磁共振成像方法引入了重要的新的研究方向。为了实现这些目标，我们将进行模拟以模拟预期的人体条件，进行模体实验以确定技术的准确性，并进行人体实验以在体内验证该方法。拟议的研究将在四年内进行，早期部分致力于技术开发，后期部分致力于志愿者的潜在临床应用。这些研究将包括：成像大脑组织的敏感性，测量主要血管的氧饱和度，并收集全脑血管的动脉和静脉信息。这些方法还将在使用和不使用造影剂的情况下进行评估，以测试提案中的血管造影要素。这一研究项目的成功将为更好地检测神经和血管疾病提供一种手段。 公共健康回顾：磁化率加权成像(SWI)是一种新的高分辨率磁共振成像方法，它使检测脑中微出血和铁含量成为可能。这种对血液产品(如含铁血黄素)和铁蛋白形式的铁的精致敏感性使SWI成为创伤、中风、多发性硬化症和肿瘤等神经系统疾病成像的首选方法。最近，SWI也已可用于临床世界的日常使用，因此，其持续的技术开发对于患者正确诊断这些疾病至关重要。

DESCRIPTION (provided by applicant): Susceptibility weighted imaging (SWI) has become an important new tool for diagnosing disease in the brain. It is used to study the vasculature of the brain, to detect iron in the brain and to visualize micro-hemorrhages. The method relies on changes in susceptibility between tissues that lead to the introduction of phase differences between tissues and to signal loss. It has been shown to be a powerful means to better diagnose trauma, stroke and tumors and detect changes in brain function. We wish to continue the development of SWI to: a) make it more clinically viable by reducing phase processing artifacts; b) evaluate susceptibility itself by creating a susceptibility map of human tissue; c) study its role as a new MR angiographic method by simultaneously collecting MRA and SWI data; and d) speed up its acquisition time to less than 5 minutes for whole brain coverage, independent of any parallel imaging gain factor. The solution of these problems offers not only an advance over the current use of SWI but also the introduction of important new research directions in magnetic resonance imaging methods. To accomplish these goals, we will perform simulations to mimic expected human conditions, perform phantom experiments to establish the accuracy of the techniques, and perform human experiments to validate the methodology in vivo. The proposed research will take place over four years with the early parts devoted to technical development and the latter parts to potential clinical applications on volunteers. These studies will include: imaging the susceptibility of tissues in the brain, measuring oxygen saturation in major vessels and collecting whole brain vascular information for the arteries and veins. These methods will also be evaluated with and without contrast agents when it comes to testing the angiographic elements of the proposal. The success of this research program will offer a means to better detect neurological and vascular disease. PUBLIC HEALTH REVELANCE: Susceptibility Weighted Imaging (SWI) is a new high resolution magnetic resonance imaging method that makes it possible to detect microhemorrhages and iron content in the brain. This exquisite sensitivity to iron in the form of blood products (such as hemosiderin) and ferritin makes SWI the method of choice for imaging neurological diseases such as trauma, stroke, multiple sclerosis, and tumors. Recently, SWI has also become available to the clinical world for every day use and therefore its continued technical development is of paramount importance for the proper diagnosis of these diseases in patients.