Membrane Proteins - Structure and Mechanism

膜蛋白 - 结构和机制

• 批准号: 6571735
• 负责人: JOSEPH J FALKE
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-10 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6571735
• 关键词: meeting /conference /symposium; membrane proteins; protein structure function; travel

DESCRIPTION (provided by applicant): The Keystone Conference entitled "Membrane Protein Structure and Mechanism" will meet February 4-9, 2003 in Taos, New Mexico. The conference will feature presentations by both established and beginning investigators in the rapidly advancing field of membrane proteins. Approximately 30% of the human genome may encode transmembrane and peripheral membrane proteins which are critical to the regulation and function of most cellular signaling pathways and metabolic systems. Moreover, most current pharmaceutical agents are directed toward membrane proteins. Yet progress toward a molecular understanding of membrane protein structure and mechanism has been comparatively slow until recent years. Currently, a wide array of sophisticated physical, chemical and biochemical methods have begun to elucidate basic structural and mechanistic features of the major functional subclasses of membrane proteins, including transmembrane channels, receptors, transporters, and peripheral membrane proteins. The proposed meeting is unique, since no other conference of this size brings together leading researchers focusing on all the major classes of membrane proteins to compare their latest findings, discuss current controversies, and disseminate their newest experimental approaches. Moreover, the small size and informal format of the meeting encourages interactions between senior investigators, beginning investigators, postdocs and students, thereby providing a valuable training environment. Participants in the meeting will see, in many cases for the first time, presentations describing recently solved high resolution structures of a transmembrane anion channel, a membrane-spanning chemotaxis receptor, an ABC transmembrane transporter, and multiple peripheral membrane proteins. Other presentations will describe the structural and chemical events that occur as membrane proteins cycle between different functional states including opened/closed, on/off, inward/outward-facing, bound/free. Overall, the conference will provide a forum in which membrane protein researchers come together to present exciting new results with broad, significant implications for membrane protein structure and mechanism.

描述（由申请人提供）：Keystone会议题为“膜蛋白结构和机制”将于2003年2月4日至9日在新墨西哥州的陶斯举行。会议将由膜蛋白快速发展领域的既定和开始的研究人员进行介绍。大约30%的人类基因组可以编码跨膜和外周膜蛋白，这些蛋白对大多数细胞信号传导途径和代谢系统的调节和功能至关重要。此外，大多数当前的药剂针对膜蛋白。然而，直到最近几年，对膜蛋白结构和机制的分子理解的进展一直相对缓慢。目前，各种复杂的物理、化学和生物化学方法已经开始阐明膜蛋白主要功能亚类的基本结构和机制特征，包括跨膜通道、受体、转运蛋白和外周膜蛋白。拟议的会议是独一无二的，因为没有其他这样规模的会议汇集了专注于所有主要类别的膜蛋白的领先研究人员，以比较他们的最新发现，讨论当前的争议，并传播他们的最新实验方法。此外，会议规模小，形式非正式，鼓励高级研究人员之间的互动，新的研究人员，博士后和学生，从而提供了一个宝贵的培训环境。 与会者将看到，在许多情况下第一次，介绍描述最近解决的跨膜阴离子通道，跨膜趋化性受体，ABC跨膜转运蛋白和多种外周膜蛋白的高分辨率结构。其他演讲将描述膜蛋白在不同功能状态之间循环时发生的结构和化学事件，包括打开/关闭，打开/关闭，向内/向外，结合/自由。总的来说，会议将提供一个论坛，膜蛋白研究人员聚集在一起，提出令人兴奋的新结果，对膜蛋白结构和机制具有广泛的，重大的影响。