Interdisciplinary Predoctoral Training in Molecular Biophysics

摘要 这项续签提案寻求继续支持T32分子生物物理学博士前 科罗拉多大学博尔德分校(CU)培训计划，目前是NIH和CU的第14个年头 支持。生物物理学培训计划的目标是准备出类拔萃、积极进取的 生物物理学专业学生从事富有成效的研究事业。39名培训教员是一位杰出的， 来自5个博士授予单位的国际公认的研究人员小组：生物化学、化学和 生物工程、化学、分子、细胞与发育生物学和物理学。这些 教师和他们的学生正在使用最先进的生物物理方法来阐明 生物学中大分子结构、动力学、机理和功能的基本方面 从单分子到复杂的多组分组件再到活细胞的各种系统。许多. 这些项目侧重于与人类健康和疾病直接相关的问题。 生物物理学是博尔德校区增长最快的研究领域。在39个电流中 培训教师，自该项目开始以来已招聘了21人，其中包括去年的4人。生物物理学 培训计划一直是这一增长背后的关键推动力。培训计划，联合 在NIH和大学的资金支持下，建立了一个蓬勃发展的生物物理社区，拥有广泛的 不同实验室和部门的生物物理学家之间的合作。此外，该计划 为生物物理学博士前学生提供严格、创新的培训，确保这些学生 获得开展尖端生物物理研究所需的广泛的跨学科基础。 必修课程包括专门为该项目开发的生物物理课程和 研究性课程的负责任行为。第一年的培训包括课程作业、实验室 轮换和教学职责。第二年的培训包括额外的课程作业和 在博士候选人口试中为计划中的论文项目辩护。第二年， 学生每年都会与一个教师委员会会面，该委员会对他们的论文提供独立的反馈 研究。在所有培训年中，定期举办生物物理学研讨会、超级小组会议和职业生涯 发展活动产生了额外的培训经验，并促进了强有力的沟通和 生物物理学学生、教师和实验室之间的合作。 在本供资期间，培训方案在多个方面取得了很大进展 维度：1)招聘越来越多的高素质教职员工和学生；2) 通过录取增加参与率，3)提高任职人数不足的参与率和毕业率 团队，4)培训创新，5)强大的出版、毕业、博士后和职业生涯 学员的就业率，以及6)培训实验室之间的多次合作。

SUMMARY This renewal proposal seeks continuing support for the T32 Molecular Biophysics Predoctoral Training Program at the University of Colorado, Boulder (CU), currently in its 14th year of NIH and CU support. The goal of the Biophysics Training Program is to prepare exceptional, highly motivated biophysics students for productive research careers. The 39 training faculty are an outstanding, internationally recognized group of investigators from 5 Ph.D.-granting units: Biochemistry, Chemical & Biological Engineering, Chemistry, Molecular, Cellular & Developmental Biology, and Physics. These faculty, together with their students, are using state-of-the-art biophysical methods to elucidate fundamental aspects of macromolecular structure, dynamics, mechanism, and function in biological systems ranging from single molecules to complex, multi-component assemblies to living cells. Many of these projects focus on questions of direct relevance to human health and disease. Biophysics is the most rapidly growing research field on the Boulder campus. Of the 39 current training faculty, 21 were hired since the program began, including 4 in the past year. The Biophysics Training Program has been a key driving force behind this growth. The training program, jointly supported by NIH and University funds, has established a thriving biophysical community with extensive collaborations among biophysicists in different laboratories and departments. Moreover, the program provides rigorous, innovative training for predoctoral students of biophysics, ensuring that such students receive the broad, interdisciplinary foundation needed to carry out cutting edge biophysical research. Required coursework includes biophysical courses developed specifically for the program and a Responsible Conduct of Research course. Training during the first year includes coursework, laboratory rotations, and teaching duties. Training during the second year includes additional coursework and defense of the planned thesis project in an oral PhD candidacy exam. Following the second year, students meet yearly with a faculty committee that provides independent feedback on their thesis research. In all training years, regular Biophysics Seminars, Supergroup meetings and career development activities yield additional training experiences and stimulate strong communication and collaboration between biophysical students, faculty, and laboratories. During the current funding period, the training program has exhibited strong progress in multiple dimensions as evidenced by 1) recruitment of growing numbers of high quality faculty and students, 2) increased participation by matriculates, 3) increased participation and graduation of underrepresented groups, 4) innovations in training, 5) strong publication, graduation, and postdoctoral and career placement rates of trainees, and 6) multiple collaborations between training laboratories.