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Interdisciplinary Predoctoral Training in Molecular Biophysics

分子生物物理学跨学科博士前培训

基本信息

批准号：
10172917
负责人：
JOSEPH J FALKE
金额：
$ 36.66万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10172917
关键词：
Biophysics Molecular Training pre-doctoral

项目摘要

SUMMARY This renewal proposal seeks continuing support for the T32 Molecular Biophysics Predoctoral Training Program at the University of Colorado, Boulder (CU), currently in its 14th year of NIH and CU support. The goal of the Biophysics Training Program is to prepare exceptional, highly motivated biophysics students for productive research careers. The 39 training faculty are an outstanding, internationally recognized group of investigators from 5 Ph.D.-granting units: Biochemistry, Chemical & Biological Engineering, Chemistry, Molecular, Cellular & Developmental Biology, and Physics. These faculty, together with their students, are using state-of-the-art biophysical methods to elucidate fundamental aspects of macromolecular structure, dynamics, mechanism, and function in biological systems ranging from single molecules to complex, multi-component assemblies to living cells. Many of these projects focus on questions of direct relevance to human health and disease. Biophysics is the most rapidly growing research field on the Boulder campus. Of the 39 current training faculty, 21 were hired since the program began, including 4 in the past year. The Biophysics Training Program has been a key driving force behind this growth. The training program, jointly supported by NIH and University funds, has established a thriving biophysical community with extensive collaborations among biophysicists in different laboratories and departments. Moreover, the program provides rigorous, innovative training for predoctoral students of biophysics, ensuring that such students receive the broad, interdisciplinary foundation needed to carry out cutting edge biophysical research. Required coursework includes biophysical courses developed specifically for the program and a Responsible Conduct of Research course. Training during the first year includes coursework, laboratory rotations, and teaching duties. Training during the second year includes additional coursework and defense of the planned thesis project in an oral PhD candidacy exam. Following the second year, students meet yearly with a faculty committee that provides independent feedback on their thesis research. In all training years, regular Biophysics Seminars, Supergroup meetings and career development activities yield additional training experiences and stimulate strong communication and collaboration between biophysical students, faculty, and laboratories. During the current funding period, the training program has exhibited strong progress in multiple dimensions as evidenced by 1) recruitment of growing numbers of high quality faculty and students, 2) increased participation by matriculates, 3) increased participation and graduation of underrepresented groups, 4) innovations in training, 5) strong publication, graduation, and postdoctoral and career placement rates of trainees, and 6) multiple collaborations between training laboratories.

总结该更新建议寻求继续支持T32分子生物物理学博士预科培训计划在科罗拉多大学，博尔德（CU），目前在其第14年的NIH和CU 支持.生物物理学培训计划的目标是准备特殊的，高度积极的生物物理学专业的学生进行富有成效的研究。39名培训教师是一个杰出的，国际公认的研究小组从5博士-授予单位：生物化学、化学与生物工程，化学，分子，细胞和发育生物学，物理学。这些教师，连同他们的学生，正在使用最先进的生物物理方法来阐明生物学中大分子结构、动力学、机制和功能的基本方面从单分子到复杂的多组分组装体再到活细胞。许多这些项目侧重于与人类健康和疾病直接相关的问题。生物物理学是博尔德校区发展最快的研究领域。当前的39个培训教师，21人被雇用以来，该计划开始，其中4人在过去一年。生物物理培训计划一直是这一增长背后的关键驱动力。培训计划，联合在NIH和大学基金的支持下，建立了一个蓬勃发展的生物物理社区，不同实验室和部门的生物药理学家之间的合作。此外，该方案为生物物理学的博士前学生提供严格的创新培训，确保这些学生获得开展前沿生物物理研究所需的广泛的跨学科基础。必修课程包括专门为该计划开发的生物物理课程和负责任的研究过程。第一年的培训包括课程作业、实验室轮换和教学职责第二年的培训包括额外的课程，在博士候选人口试中对计划中的论文项目进行答辩。第二年之后，学生们每年与一个教师委员会会面，该委员会对他们的论文提供独立的反馈 research.在所有的培训年，定期生物物理研讨会，超级小组会议和职业生涯发展活动产生更多的培训经验，促进强有力的沟通，生物物理学学生，教师和实验室之间的合作。在目前的资助期间，培训计划在多个方面取得了很大进展。这些方面的证据是：1）招聘越来越多的高素质教师和学生，2）（3）代表性不足的学生的参与和毕业人数增加集团，4）创新的培养，5）强大的出版，毕业，博士后和职业生涯学员的安置率，以及6）培训实验室之间的多种合作。

项目成果

期刊论文数量（243）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging.

DOI：
10.1002/adma.201905366
发表时间：
2020-07
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
0
作者：
Yavitt FM;Brown TE;Hushka EA;Brown ME;Gjorevski N;Dempsey PJ;Lutolf MP;Anseth KS
通讯作者：
Anseth KS

Thermodynamic origins of monovalent facilitated RNA folding.

DOI：
10.1021/bi201420a
发表时间：
2012-05-08
期刊：
BIOCHEMISTRY
影响因子：
2.9
作者：
Holmstrom, Erik D.;Fiore, Julie L.;Nesbitt, David J.
通讯作者：
Nesbitt, David J.

Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange.

DOI：
10.1016/j.biomaterials.2018.03.060
发表时间：
2018-09
期刊：
Biomaterials
影响因子：
14
作者：
Brown TE;Carberry BJ;Worrell BT;Dudaryeva OY;McBride MK;Bowman CN;Anseth KS
通讯作者：
Anseth KS

The DNA-Binding High-Mobility Group Box Domain of Sox Family Proteins Directly Interacts with RNA In Vitro.

DOI：
10.1021/acs.biochem.2c00218
发表时间：
2022-05-05
期刊：
BIOCHEMISTRY
影响因子：
2.9
作者：
Hamilton, Desmond J.;Hein, Abigail E.;Holmes, Zachariah E.;Wuttke, Deborah S.;Batey, Robert T.
通讯作者：
Batey, Robert T.

Tools and techniques for illuminating the cell biology of zinc.

阐明锌细胞生物学的工具和技术。