Gordon Conference on Glycolipid & Sphingolipid Biology

描述（由申请人提供）：2002年请求部分支持 戈登糖脂和鞘脂生物学研究会议，将举行 1月26日至2月1日在加州文图拉假日酒店举行。的目的 会议将鼓励在世界范围内交流思想和信息， 社区的科学家谁在糖脂的前沿工作， 鞘脂研究以及提供一个环境， 从其他科学学科可以学习，并有助于，这一点 快速发展的领域。鞘脂参与许多生物 过程-如细胞-细胞识别，细胞-基质粘附，免疫 调节，细胞生长和分化，但只是在过去的十年中， 这些功能的分子基础变得清晰，即这些功能 的（糖）鞘脂存在于其复杂的头基（作为调节剂 膜结构、细胞间相互作用、受体功能等）和 脂质骨架（神经酰胺，鞘氨醇，鞘氨醇1-磷酸等， 作为第一和第二信使）。此外，这种理解不仅 让我们深入了解正常的细胞调节，同时也了解 毒素和毒物（包括癌症化学预防和化学治疗 试剂）杀死细胞。这次戈登会议的一个重要方面是， 汇集了在许多不同学科工作的科学家，如 基础生物化学、遗传学、发育生物学、癌症化学预防和 化学疗法、退行性疾病、毒理学和环境卫生 以理工科为重由于这种广度（和深度），戈登会议 糖脂和鞘脂生物学在以下方面发挥着独特而有价值的作用： 推进这一领域。将寻求广泛的发言者和与会者 包括研究生和研究生，以及 初级调查员与本系列中的前几次戈登会议一样， 来自美国以外国家的参与者比例很高， 以及妇女和少数民族的参与。鼓励与会者 既参加正式的讲座/讨论会，也不太正式。 in poster海报presentations介绍.平台会议将涵盖前沿研究 在基础鞘脂生物学（例如生物物理学、代谢、细胞内 贩运以及基因组学和基因靶向方法，现代分析 方法学，如HPLC串联质谱法，和研究中， 鞘脂在细胞调节，特别是细胞生长中的体内作用 凋亡），并将强调这些新的范式和 实验方法正在提供疾病的病因学、预防和 疗法

DESCRIPTION(provided by applicant): Partial support is requested for the 2002 Gordon Research Conference on Glycolipid and Sphingolipid Biology, to be held at the Holiday Inn, Ventura, CA from January 26 to February 1. The purpose of the conference is to encourage the transfer of ideas and information within the community of scientists who work at the forefront of glycolipid and sphingolipid research as well as to provide an environment where investigators from other scientific disciplines can learn about, and contribute to, this rapidly evolving field. Sphingolipids participate in many biological processes--such as cell-cell recognition, cell-substratum adhesion, immune regulation, cell growth and differentiation, but only in the past decade have the molecular bases for these functions become clear, i.e. that the functions of (glyco)sphingolipids reside in both their complex headgroups (as modulators of membrane structure, cell-cell interactions, receptor functions, etc.) and the lipid backbones (ceramide, sphingosine, sphingosine 1-phosphate and others, as first and second messengers). Furthermore, this understanding is not only giving insight into normal cell regulation, but also, into the pathways whereby toxins and toxicants (including cancer chemopreventive and chemotherapeutic agents) kill cells. An important aspect of this Gordon Conference is that it brings together scientists that work in many different disciplines, such as basic biochemistry, genetics, developmental biology, cancer chemoprevention and chemotherapy, degenerative disorders, toxicology and environmental health sciences. Because of this breadth (and depth), the Gordon Conference on Glycolipid and Sphingolipid Biology plays a unique and valuable role in advancing this field. A broad range of speakers and participants will be sought for the 2002 Conference, including graduate and postgraduate students, and junior investigators. As with previous Gordon Conferences in this series, there will be a high percentage of participants from countries outside the U.S. as well as participation by women and minorities. Conferees will be encouraged to participate both in the formal lecture/discussion sessions, and less formally in poster presentations. The platform sessions will cover leading edge research in basic sphingolipid biology (e.g. biophysics, metabolism, intracellular trafficking as well as genomics and gene targeting approaches, modem analytical methodologies such as HPLC tandem mass spectrometry , and studies of the in vivo roles of sphingolipids in cell regulation, particularly cell growth and apoptosis) and will emphasize the insights that these new paradigms and experimental approaches are providing for disease etiology, prevention and therapy.