Highly Differentiated Tissue Culture Models of Melanoma
Highly Differentiated Tissue Culture Models of Melanoma
批准号:
6442624
负责人:
MITCHELL KLAUSNER
金额:
$15.22万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-08-15 至 2003-03-31
中文摘要
资料说明(申请人提供):除
在女性中,皮肤黑色素瘤(CM)的发病率比任何
其他癌症。目前的估计是,美国每75个人中就有一个
会在他或她的有生之年感染CM。黑色素瘤的不同阶段
然而,已经被很好地描述为设计出改进的治疗方法
让患者活得更长、更有成效,更好地了解
CM的进步是必要的。这项提议的目的是生产高质量的产品。
CM进展不同阶段的差异化组织培养模型。
在第一阶段,来自不同疾病状态的CM细胞株将被
在单层培养中扩增并鉴定。使用无血清培养
系统中,这些细胞将被结合到一个有机的、全厚度的
皮肤模型以产生组织重建,该组织重建平行于
Cm在体内。组织将在形态、肿瘤等方面进行表征
进展和黏附受体。最后,组织的重复性
将对模型进行调查。
英文摘要
DESCRIPTION (provided by applicant): With the exception of lung cancer in
women, the incidence of cutaneous melanoma (CM) is increasing faster than any
other cancer. Current estimates are that one of every 75 individuals in the US
will contract CM during his or her lifetime. The various stages of melanoma
have been well described, however, to devise improved treatments allowing
patients to lead longer and more productive lives, a better understanding of
progression of CM is needed. The purpose of this proposal is to produce highly
differentiated, tissue culture models of the various stages of CM progression.
During Phase I, cell lines from the various disease states of CM will be
expanded in monolayer culture and characterized. Using a serum free culture
system, these cells will be incorporated into an organotypic, full thickness
skin model to produce tissue reconstructs which parallel the various stages of
CM in vivo. The tissues will be characterized in terms of morphology, tumor
progression, and adhesion receptors. Finally, reproducibility of the tissue
models will be investigated.
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会议论文
Reconstructed Human Oral Tissues
-
批准号:6785440
-
项目类别:
-
资助金额:$39.18万
-
财政年份:2003
-
负责人:MITCHELL KLAUSNER
-
依托单位:
Reconstructed Human Oral Tissues
-
批准号:6689242
-
项目类别:
-
资助金额:$48.29万
-
财政年份:2003
-
负责人:MITCHELL KLAUSNER
-
依托单位:
In Vitro Skin Model for Percutaneous Absorption Studies
-
批准号:6481054
-
项目类别:
-
资助金额:$18.14万
-
财政年份:2002
-
负责人:MITCHELL KLAUSNER
-
依托单位:
HUMAN TISSUE MODEL FOR HETEROSEXUAL HIV INFECTION
-
批准号:6156165
-
项目类别:
-
资助金额:$28.54万
-
财政年份:2000
-
负责人:MITCHELL KLAUSNER
-
依托单位:
RECONSTRUCTED HUMAN GINGIVAL TISSUE
-
批准号:6014566
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2000
-
负责人:MITCHELL KLAUSNER
-
依托单位:
Human Tissue Model For Heterosexual HIV Transmission
-
批准号:6486337
-
项目类别:
-
资助金额:$53.34万
-
财政年份:2000
-
负责人:MITCHELL KLAUSNER
-
依托单位:
Human Tissue Model For Heterosexual HIV Transmission
-
批准号:6626084
-
项目类别:
-
资助金额:$53.96万
-
财政年份:2000
-
负责人:MITCHELL KLAUSNER
-
依托单位:
IMMORTALIZED HUMAN LANGERHANS CELLS
-
批准号:2714952
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1998
-
负责人:MITCHELL KLAUSNER
-
依托单位:
RECONSTRUCTED SKIN MODEL CONTAINING LANGERHANS CELLS
-
批准号:2432859
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1997
-
负责人:MITCHELL KLAUSNER
-
依托单位:
DIFFERENTIATED AIRWAY EPITHELIAL CULTURES
-
批准号:2792623
-
项目类别:
-
资助金额:$38.85万
-
财政年份:1997
-
负责人:MITCHELL KLAUSNER
-
依托单位:
DIFFERENTIATED AIRWAY EPITHELIAL CULTURES
-
批准号:6124817
-
项目类别:
-
资助金额:$39.03万
-
财政年份:1997
-
负责人:MITCHELL KLAUSNER
-
依托单位:
DIFFERENTIATED AIRWAY EPITHELIAL CULTURES
-
批准号:2017769
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1997
-
负责人:MITCHELL KLAUSNER
-
依托单位:
ORGANOTYPIC SKIN MODEL CONTAINING MELANOCYTES
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批准号:2082631
-
项目类别:
-
资助金额:$7.5万
-
财政年份:1994
-
负责人:MITCHELL KLAUSNER
-
依托单位:
ORGANOTYPIC SKIN MODELS CONTAINING MELANOCYTES
-
批准号:2712456
-
项目类别:
-
资助金额:$37.12万
-
财政年份:1994
-
负责人:MITCHELL KLAUSNER
-
依托单位:
ORGANOTYPIC SKIN MODELS CONTAINING MELANOCYTES
-
批准号:2006400
-
项目类别:
-
资助金额:$37.85万
-
财政年份:1994
-
负责人:MITCHELL KLAUSNER
-
依托单位:
CULTURED CORNEAL EPITHELIUM--DRAIZE TEST REPLCEMENT
-
批准号:2155496
-
项目类别:
-
资助金额:$29.77万
-
财政年份:1993
-
负责人:MITCHELL KLAUSNER
-
依托单位:
CULTURED CORNEAL EPITHELIUM--DRAIZE TEST REPLCEMENT
-
批准号:2155495
-
项目类别:
-
资助金额:$34.28万
-
财政年份:1993
-
负责人:MITCHELL KLAUSNER
-
依托单位:
ORGANOTYPIC SKIN CULTURES WITH IMPROVED BARRIERS
-
批准号:3490877
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1993
-
负责人:MITCHELL KLAUSNER
-
依托单位:
CULTURED CORNEAL EPITHELIUM--DRAIZE TEST REPLACEMENT
-
批准号:3496772
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1993
-
负责人:MITCHELL KLAUSNER
-
依托单位:
CELL CULTURE SURFACES FOR BONE RESEARCH
-
批准号:3490633
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1991
-
负责人:MITCHELL KLAUSNER
-
依托单位:
海外基金