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Highly Differentiated Tissue Culture Models of Melanoma

Highly Differentiated Tissue Culture Models of Melanoma
黑色素瘤的高度分化组织培养模型
批准号:
6442624
负责人:
MITCHELL KLAUSNER
金额:
$15.22万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-08-15 至 2003-03-31

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中文摘要
翻译
描述(由申请人提供):除肺癌外
英文摘要
DESCRIPTION (provided by applicant): With the exception of lung cancer in women, the incidence of cutaneous melanoma (CM) is increasing faster than any other cancer. Current estimates are that one of every 75 individuals in the US will contract CM during his or her lifetime. The various stages of melanoma have been well described, however, to devise improved treatments allowing patients to lead longer and more productive lives, a better understanding of progression of CM is needed. The purpose of this proposal is to produce highly differentiated, tissue culture models of the various stages of CM progression. During Phase I, cell lines from the various disease states of CM will be expanded in monolayer culture and characterized. Using a serum free culture system, these cells will be incorporated into an organotypic, full thickness skin model to produce tissue reconstructs which parallel the various stages of CM in vivo. The tissues will be characterized in terms of morphology, tumor progression, and adhesion receptors. Finally, reproducibility of the tissue models will be investigated.
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Reconstructed Human Oral Tissues
  • 批准号:
    6689242
  • 项目类别:
  • 资助金额:
    $48.29万
  • 财政年份:
    2003
  • 负责人:
    MITCHELL KLAUSNER
  • 依托单位:
Reconstructed Human Oral Tissues
  • 批准号:
    6785440
  • 项目类别:
  • 资助金额:
    $39.18万
  • 财政年份:
    2003
  • 负责人:
    MITCHELL KLAUSNER
  • 依托单位:
In Vitro Skin Model for Percutaneous Absorption Studies
  • 批准号:
    6481054
  • 项目类别:
  • 资助金额:
    $18.14万
  • 财政年份:
    2002
  • 负责人:
    MITCHELL KLAUSNER
  • 依托单位:
HUMAN TISSUE MODEL FOR HETEROSEXUAL HIV INFECTION
  • 批准号:
    6156165
  • 项目类别:
  • 资助金额:
    $28.54万
  • 财政年份:
    2000
  • 负责人:
    MITCHELL KLAUSNER
  • 依托单位:
海外基金