Early formation of the preplate establishes the cerebral cortex

前板的早期形成建立了大脑皮层

• 批准号: DP140101499
• 负责人: Prof Linda Richards
• 金额: $ 47.45万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-06-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101499
• 关键词: Early; formation; preplate; establishes; cerebral

The cerebral cortex is arguably the most complex area of the brain due to its ability to process and integrate a wide variety of information in a seamless manner. To understand how this occurs, it is essential to understand how the cerebral cortex is built during embryonic life. The focus of this project is on the formation of the very earliest neurons of the cortex, called preplate neurons. This project aims to: test a new model for preplate development with regards to their origin; their function in formation of the cerebral cortex; and the the molecular mechanisms underlying their development. This work provides a developmental framework for understanding how the cerebral cortex is established.

大脑皮层可以说是大脑中最复杂的区域，因为它能够以无缝的方式处理和整合各种信息。要了解这是如何发生的，必须了解大脑皮层在胚胎期是如何构建的。这个项目的重点是皮层最早期神经元的形成，称为前板神经元。该项目旨在：测试一种新的前板发育模型，包括它们的起源;它们在大脑皮层形成中的功能;以及它们发育的分子机制。这项工作为理解大脑皮层是如何建立的提供了一个发展框架。