Cellular and molecular regulation of interhemispheric fusion

半球间融合的细胞和分子调控

• 批准号: nhmrc : 1048849
• 负责人: Prof Linda Richards
• 金额: $ 29.97万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cellular-molecular-regulation-interhemispheric-fusion/112042
• 关键词: Cellular; molecular; regulation; interhemispheric; fusion

In the developing brain, the two cerebral hemispheres undergo interhemispheric fusion to allow commissural fibres to cross the midline. Lack of interhemispheric fusion results in agenesis of the corpus callosum and may manifest as an interhemispheric cyst in acallosal patients. This project will investigate the cellular and molecular mechanisms that regulate interhemispheric fusion, including removal of the leptomeninges, astroglial differentiation and the formation of adherens junctions at the interhemispheric fissure to mediate fusion.

在发育中的大脑中，两个大脑半球进行半球间融合，使连合纤维穿过中线。缺乏半球间融合会导致胼胝体发育不全，并且在无胼胝体患者中可能表现为半球间囊肿。该项目将研究调节半球间融合的细胞和分子机制，包括去除软脑膜、星形胶质细胞分化以及在半球间裂处形成粘附连接以介导融合。