Unravelling the principles of bilateral brain wiring

揭示双侧大脑接线的原理

• 批准号: DP160103958
• 负责人: Prof Linda Richards
• 金额: $ 41.86万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160103958
• 关键词: Unravelling; principles; bilateral; brain; wiring

This project seeks to investigate the molecular principles of brain wiring in mammals and how small changes can generate complex outcomes. Neurons in the mammalian brain must be precisely wired together for the brain to function correctly. The project aims to identify the molecular and cellular rules governing commissural wiring in the mammalian cortex to determine how the largest fibre tract in the human brain, the corpus callosum, evolved. This may have involved modifications in mechanisms affecting axon guidance that differ between placentals and marsupials. The project investigates the regulatory gene networks determining commissural neuron fate, the regulation of axon guidance components, and the influence of surrounding brain tissue on the development of commissural connections.

该项目旨在研究哺乳动物大脑布线的分子原理，以及微小的变化如何产生复杂的结果。哺乳动物大脑中的神经元必须精确地连接在一起，才能使大脑正常运作。该项目旨在确定哺乳动物皮层中控制连合布线的分子和细胞规则，以确定人类大脑中最大的纤维束胼胝体是如何进化的。这可能涉及影响轴突导向的机制的修改，这在胎盘动物和有袋动物之间是不同的。该项目研究了决定连合神经元命运的调控基因网络，轴突导向成分的调控，以及周围脑组织对连合连接发育的影响。