Specialized glial cells within the hippocampus of the brain regulate important morphological events in embryonic development

大脑海马内的特殊神经胶质细胞调节胚胎发育中的重要形态事件

• 批准号: DP0984643
• 负责人: Prof Linda Richards
• 金额: $ 54.32万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984643
• 关键词: Specialized; glial; cells; within; hippocampus

Memories of past experiences, and our ability to learn new information, is processed in a region of the brain called the hippocampus. In order for this to occur, the cells that make up the hippocampus must form correctly during embryonic development. This proposal investigates the cellular and molecular mechanisms regulating hippocampal formation. The national benefit of this work is to provide basic knowledge about the processes that underlie correct brain formation and function, and to understand what processes are disrupted when the brain fails to function correctly. Such disruptions lead to mental retardation and learning difficulties, and in the aged, an inability to form and store new memories, as occurs in dementia.

对过去经历的记忆以及我们学习新信息的能力是在大脑中称为海马体的区域进行处理的。为了实现这一点，构成海马体的细胞必须在胚胎发育过程中正确形成。 该提案研究了调节海马形成的细胞和分子机制。这项工作的国家利益是提供有关大脑正确形成和功能过程的基本知识，并了解当大脑无法正常运行时哪些过程会受到干扰。这种干扰会导致智力低下和学习困难，而老年人则无法形成和存储新的记忆，就像痴呆症一样。