Control of cellular differentiation in the developing brain
Control of cellular differentiation in the developing brain
批准号:
DP200102363
负责人:
Prof Linda Richards
金额:
$30.66万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2020
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2020-01-01 至 2022-01-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This project aims to understand how mature brain cells form during foetal life. The central hypothesis is that a specific transcription factor family, called NFI, regulates the epigenetic state of the cell, allowing chromatin accessibility and subsequent transcriptional activation and repression to control cellular differentiation. Aims 1 and 2 will investigate how brain cells transition from proliferating progenitor cells to differentiated mature cell types. Aim 3 will investigate how differentiation is maintained in the adult brain. Methods used involve genome and chromatin analyses of cells isolated from transgenic mouse models. Outcomes and benefits are substantial knowledge gain applicable to stem cell regulation and brain health.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Corpus callosum function in decision making
-
批准号:DP210101712
-
项目类别:Discovery Projects
-
资助金额:$10.12万
-
财政年份:2021
-
负责人:Prof Linda Richards
-
依托单位:
Normal and abnormal development of brain wiring and its impact on brain function
-
批准号:nhmrc : GNT1120615
-
项目类别:Research Fellowships
-
资助金额:$76.38万
-
财政年份:2017
-
负责人:Prof Linda Richards
-
依托单位:
Normal and abnormal development of brain wiring and its impact on brain function
-
批准号:nhmrc : 1120615
-
项目类别:Research Fellowships
-
资助金额:$52.22万
-
财政年份:2017
-
负责人:Prof Linda Richards
-
依托单位:
Unravelling the principles of bilateral brain wiring
-
批准号:DP160103958
-
项目类别:Discovery Projects
-
资助金额:$41.86万
-
财政年份:2016
-
负责人:Prof Linda Richards
-
依托单位:
Targeting of callosal axons to duplicate cortical areas in the contralateral hemisphere
-
批准号:nhmrc : 1064174
-
项目类别:Project Grants
-
资助金额:$40.06万
-
财政年份:2014
-
负责人:Prof Linda Richards
-
依托单位:
Early formation of the preplate establishes the cerebral cortex
-
批准号:DP140101499
-
项目类别:Discovery Projects
-
资助金额:$47.45万
-
财政年份:2014
-
负责人:Prof Linda Richards
-
依托单位:
Guidance mechanisms regulating the development of axonal projections from the cingulate cortex.
-
批准号:nhmrc : 1043045
-
项目类别:Project Grants
-
资助金额:$32.29万
-
财政年份:2013
-
负责人:Prof Linda Richards
-
依托单位:
Cellular and molecular regulation of interhemispheric fusion
-
批准号:nhmrc : 1048849
-
项目类别:Project Grants
-
资助金额:$29.97万
-
财政年份:2013
-
负责人:Prof Linda Richards
-
依托单位:
Molecular and activity dependent mechanisms regulating the targeting of corpus callosum axons in the contralateral hemisphere.
-
批准号:nhmrc : 1029975
-
项目类别:Project Grants
-
资助金额:$27.56万
-
财政年份:2012
-
负责人:Prof Linda Richards
-
依托单位:
Development of the cerebral cortex
-
批准号:nhmrc : 1005751
-
项目类别:Research Fellowships
-
资助金额:$58.7万
-
财政年份:2011
-
负责人:Prof Linda Richards
-
依托单位:
DCC-Robo interactions cooperate to regulate callosal axon guidance
-
批准号:nhmrc : 631466
-
项目类别:NHMRC Project Grants
-
资助金额:$25.57万
-
财政年份:2010
-
负责人:Prof Linda Richards
-
依托单位:
Specialized glial cells within the hippocampus of the brain regulate important morphological events in embryonic development
-
批准号:DP0984643
-
项目类别:Discovery Projects
-
资助金额:$54.32万
-
财政年份:2009
-
负责人:Prof Linda Richards
-
依托单位:
Nuclear Factor One genes regulate multiple aspects of cerebral cortex development
-
批准号:nhmrc : 569504
-
项目类别:NHMRC Project Grants
-
资助金额:$35.13万
-
财政年份:2009
-
负责人:Prof Linda Richards
-
依托单位:
The role of Netrin-DCC in the development of the corpus callosum
-
批准号:nhmrc : 456026
-
项目类别:NHMRC Project Grants
-
资助金额:$34.14万
-
财政年份:2007
-
负责人:Prof Linda Richards
-
依托单位:
Development of the commissural plate and its role in forebrain commissure development
-
批准号:nhmrc : 456027
-
项目类别:NHMRC Project Grants
-
资助金额:$35.31万
-
财政年份:2007
-
负责人:Prof Linda Richards
-
依托单位:
Advanced Cell Labelling and Imaging Facility
-
批准号:LE0668246
-
项目类别:Linkage Infrastructure, Equipment and Facilities
-
资助金额:$26.67万
-
财政年份:2006
-
负责人:Prof Linda Richards
-
依托单位:
Regulation of cortical development by Nfi genes.
-
批准号:nhmrc : 401616
-
项目类别:NHMRC Project Grants
-
资助金额:$31.49万
-
财政年份:2006
-
负责人:Prof Linda Richards
-
依托单位:
Research Fellowship - Grant ID:401658
-
批准号:nhmrc : 401658
-
项目类别:NHMRC Research Fellowships
-
资助金额:$40.48万
-
财政年份:2006
-
负责人:Prof Linda Richards
-
依托单位:
国内基金
海外基金
登录
查看更多内容
基于MFSD2A调控血迷路屏障跨细胞囊泡转运机制的噪声性听力损失防治研究
-
批准号:82371144
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:汪雪玲
-
依托单位:
长寿基因SIRT7调控核苷酸切除修复通路的机制研究
-
批准号:32100605
-
项目类别:青年科学基金项目(C类)
-
资助金额:30.0万元
-
批准年份:2021
-
负责人:耿安珂
-
依托单位:
溶酶体蛋白LAPTM4B通过与Xc-系统相互作用调控谷胱甘肽代谢的机制研究
-
批准号:32100623
-
项目类别:青年科学基金项目(C类)
-
资助金额:30.0万元
-
批准年份:2021
-
负责人:周可成
-
依托单位:
小鼠肺分支早期发育中肺上皮单细胞的时-空转录组的建立与分析
-
批准号:32070795
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:蔡军
-
依托单位:
乳腺癌上皮间质转化中核苷酸代谢相关的功能蛋白发现和机理研究
-
批准号:32070748
-
项目类别:面上项目
-
资助金额:54.0万元
-
批准年份:2020
-
负责人:戴凌云
-
依托单位:
rhTβ4增强间充质干细胞调节T细胞代谢重塑治疗干眼的机制研究
-
批准号:32000530
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2020
-
负责人:陈小鸟
-
依托单位:
胰岛素和细菌信号协同调节巨噬细胞免疫反应的作用
-
批准号:92057105
-
项目类别:重大研究计划
-
资助金额:89.0万元
-
批准年份:2020
-
负责人:Tiffany Shy Yea Horng
-
依托单位:
一种全新的高尔基体胆固醇感应蛋白的鉴定和功能研究
-
批准号:32070755
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:钟辉
-
依托单位:
葡萄糖调节的AXIN溶酶体膜转运的分子机制
-
批准号:32070753
-
项目类别:面上项目
-
资助金额:59.0万元
-
批准年份:2020
-
负责人:李梦琪
-
依托单位:
胞浆甘氨酰-tRNA合成酶cytoGARS感知甘氨酸的分子机制及其对肝细胞癌的影响
-
批准号:32070756
-
项目类别:面上项目
-
资助金额:59.0万元
-
批准年份:2020
-
负责人:汪维
-
依托单位: