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Control of cellular differentiation in the developing brain

Control of cellular differentiation in the developing brain
大脑发育中细胞分化的控制
批准号:
DP200102363
负责人:
Prof Linda Richards
金额:
$30.66万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2020
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2020-01-01 至 2022-01-31

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中文摘要
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英文摘要
This project aims to understand how mature brain cells form during foetal life. The central hypothesis is that a specific transcription factor family, called NFI, regulates the epigenetic state of the cell, allowing chromatin accessibility and subsequent transcriptional activation and repression to control cellular differentiation. Aims 1 and 2 will investigate how brain cells transition from proliferating progenitor cells to differentiated mature cell types. Aim 3 will investigate how differentiation is maintained in the adult brain. Methods used involve genome and chromatin analyses of cells isolated from transgenic mouse models. Outcomes and benefits are substantial knowledge gain applicable to stem cell regulation and brain health.
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