Targeting of callosal axons to duplicate cortical areas in the contralateral hemisphere

将胼胝轴突瞄准对侧半球的复制皮质区域

• 批准号: nhmrc : 1064174
• 负责人: Prof Linda Richards
• 金额: $ 40.06万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-callosal-axons-contralateral-hemisphere/455105
• 关键词: Targeting; callosal; axons; duplicate; cortical

The two sides of the brain communicate via a large fibre tract called the corpus callosum. This proposal investigates how the corpus callosum is formed during embryonic and postnatal development. Specifically, we investigate how the axons that make up the corpus callosum are able to locate their precise target in the contralateral hemisphere so that the brain circuit they form will be functional. We have developed a new mouse model to discover the fundamental mechanisms regulating how the brain is wired in order to function correctly.

大脑的两侧通过一个叫做胼胝体的大纤维束进行交流。本研究旨在探讨胼胝体在胚胎和出生后发育过程中是如何形成的。具体来说，我们研究了构成胼胝体的轴突如何能够在对侧半球定位其精确的目标，以便它们形成的大脑回路发挥作用。我们开发了一种新的小鼠模型，以发现调节大脑如何连接以正确运作的基本机制。