MODELING OF NON LINEAR DYNAMICS OF RENAL AUTOREGULATION

肾脏自动调节的非线性动力学建模

基本信息

  • 批准号:
    6611238
  • 负责人:
  • 金额:
    $ 15.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-09-01 至 2003-08-31
  • 项目状态:
    已结题

项目摘要

During this past year we have made major progress on developing and applying several of the essential modeling methodologies for input/output, or nonparametric, models of point-process input neural systems such as the hippocampus. First, we have pursued development and application of adaptive estimation procedures for decomposition studies of the hippocampus. Using this approach, we have been able to successfully estimate linear and nonlinear properties of negative feedback elements (analogous to inhibitory interneurons) given input/output data for only the feedthrough element in the presence and absence of inhibition, i.e., without direct observations from the feedback pathway. Second, we have developed a new means for estimating input/output properties of neural elements using artificial (feedforward) neural networks, which we have demonstrated is particularly powerful for estimating higher order nonlinearities from electrophysiological data. We are particularly excited about the potential for expanding this approach for estimating higher order cross-kernels for multiple-input conditions. Third, for the first time we have applied our nonlinear systems approach at the level of intracellularly recorded synaptic potentials. We have recently modeled the closed- and open-loop AMPA and NMDA components of glutamatergic synaptic input to hippocampal neurons, have derived a representation of the dynamics of the positive feedback to the NMDA receptor-channel, and can accurately predict control EPSPs to a wide range of input patterns. In addition, the model can account for differences between closed- and open-loop NMDA receptor-mediated synaptic responses. These are two of the most widely studied receptor subtypes, as the dynamics of their interaction determine the direction and magnitude of activity-dependent synaptic plasticity in hippocampus, neocortex, and other brain regions. Finally, we have made considerable progress in developing highly efficient circuit designs for analog VLSI implementation of kernel models of hippocampal neurons, a direction that should provide the means for developing massively parallel architectures for simulating global hippocampal system properties.
在过去的一年里,我们在发展方面取得了重大进展

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DONALD J MARSH其他文献

DONALD J MARSH的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DONALD J MARSH', 18)}}的其他基金

Non-linear regulation of the renal circulation
肾循环的非线性调节
  • 批准号:
    7272819
  • 财政年份:
    2005
  • 资助金额:
    $ 15.58万
  • 项目类别:
Non-linear regulation of the renal circulation
肾循环的非线性调节
  • 批准号:
    7128122
  • 财政年份:
    2005
  • 资助金额:
    $ 15.58万
  • 项目类别:
Non-linear regulation of the renal circulation
肾循环的非线性调节
  • 批准号:
    7038686
  • 财政年份:
    2005
  • 资助金额:
    $ 15.58万
  • 项目类别:
MODELING OF NON LINEAR DYNAMICS OF RENAL AUTOREGULATION
肾脏自动调节的非线性动力学建模
  • 批准号:
    6480874
  • 财政年份:
    2001
  • 资助金额:
    $ 15.58万
  • 项目类别:
MODELING OF NON LINEAR DYNAMICS OF RENAL AUTOREGULATION
肾脏自动调节的非线性动力学建模
  • 批准号:
    6205814
  • 财政年份:
    1999
  • 资助金额:
    $ 15.58万
  • 项目类别:
MODELING OF RENAL AUTOREGULATION DYNAMICS
肾脏自动调节动力学建模
  • 批准号:
    6120735
  • 财政年份:
    1998
  • 资助金额:
    $ 15.58万
  • 项目类别:
MODELING OF RENAL AUTOREGULATION DYNAMICS
肾脏自动调节动力学建模
  • 批准号:
    6251846
  • 财政年份:
    1997
  • 资助金额:
    $ 15.58万
  • 项目类别:
THEORETICAL RENAL PHYSIOLOGY MEETING
理论肾脏生理学会议
  • 批准号:
    3434711
  • 财政年份:
    1992
  • 资助金额:
    $ 15.58万
  • 项目类别:
ARRAY PROCESSOR
阵列处理器
  • 批准号:
    3519641
  • 财政年份:
    1987
  • 资助金额:
    $ 15.58万
  • 项目类别:
SIMULATION OF THE RENAL MEDULLA
肾髓质的模拟
  • 批准号:
    3232134
  • 财政年份:
    1984
  • 资助金额:
    $ 15.58万
  • 项目类别:

相似海外基金

Molecular Imaging Biomedical Resource Core
分子成像生物医学资源核心
  • 批准号:
    10747619
  • 财政年份:
    2023
  • 资助金额:
    $ 15.58万
  • 项目类别:
Biomedical Resource Core
生物医学资源核心
  • 批准号:
    10747705
  • 财政年份:
    2023
  • 资助金额:
    $ 15.58万
  • 项目类别:
Intravital Microscopy Biomedical Resource Core
活体显微镜生物医学资源核心
  • 批准号:
    10747618
  • 财政年份:
    2023
  • 资助金额:
    $ 15.58万
  • 项目类别:
Biomedical Resource Core
生物医学资源核心
  • 批准号:
    10754083
  • 财政年份:
    2023
  • 资助金额:
    $ 15.58万
  • 项目类别:
National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)
国家电子自旋共振光谱生物医学资源 (ACERT)
  • 批准号:
    10653773
  • 财政年份:
    2022
  • 资助金额:
    $ 15.58万
  • 项目类别:
National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)
国家电子自旋共振光谱生物医学资源 (ACERT)
  • 批准号:
    10797623
  • 财政年份:
    2022
  • 资助金额:
    $ 15.58万
  • 项目类别:
National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)
国家电子自旋共振光谱生物医学资源 (ACERT)
  • 批准号:
    10430665
  • 财政年份:
    2022
  • 资助金额:
    $ 15.58万
  • 项目类别:
The 1958 Birth Cohort Biomedical Resource - facilitating access to data and samples and enhancing future utility
1958 年出生队列生物医学资源 - 促进数据和样本的获取并增强未来的效用
  • 批准号:
    G1001799/2
  • 财政年份:
    2013
  • 资助金额:
    $ 15.58万
  • 项目类别:
    Research Grant
The 1958 Birth Cohort Biomedical Resource - facilitating access to data and samples and enhancing future utility
1958 年出生队列生物医学资源 - 促进数据和样本的获取并增强未来的效用
  • 批准号:
    G1001799/1
  • 财政年份:
    2011
  • 资助金额:
    $ 15.58万
  • 项目类别:
    Research Grant
Vervet Research Colony as a Biomedical Resource
作为生物医学资源的黑长尾黑长尾猴研究群
  • 批准号:
    7894014
  • 财政年份:
    2009
  • 资助金额:
    $ 15.58万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了