BIOGENIC AMINE SYSTEMS, CRF, AND STRESS

生物胺系统、CRF 和压力

基本信息

  • 批准号:
    6637564
  • 负责人:
  • 金额:
    $ 12.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-03-01 至 2006-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (applicant's abstract): This is a proposal for a Senior Scientist Award (K05) from an investigator who has been funded by a Research Scientist Development Award (K02) for the last 10 years. Prior K02 funding advanced the PI's career by providing time to develop new approaches and foster productive collaborations. At a research level this resulted in expansion from a single to 3 major interrelated NIH-funded research programs. At a technical level, expertise went from predominantly in vivo electrophysiological approaches to including in vivo microdialysis, as well as sophisticated systems and cellular neuroanatomical techniques. At a career level, the PI established a Division of Stress Neurobiology within the Department of Psychiatry [at Hahnemann University]. In February the Division moved to the Children's Hospital of Philadelphia where the PI was offered a prestigious position as a Stokes Investigator and faculty position at the University of Pennsylvania. The proposed research plan integrates aspects of the 3 funded research programs to address the global hypothesis that the impact of corticotropin-releasing factor on biogenic amine systems is integral in the acute stress response and that stress-induced plasticity of these interactions underlies certain stress-related psychopathology. The proposed career development plan will allow the PI to develop and incorporate new cellular approaches into the experimental repertoire of systems approaches currently used to elucidate CRF-biogenic amine interactions and mechanisms underlying stress-induced plasticity. These include cellular and molecular electrophysiological techniques in in vitro slice preparations and the use of viral vectors to manipulate CRF expression in specific CRF afferents to biogenic amine nuclei. These techniques will arm the PI with a range of tools necessary to address research questions on multiple levels (from cellular to systems). A second aspect of career development is to mobilize basic and clinical investigators within the CHOP/ Upenn community who share a common interest in stress in a Center for Stress Neurobiology. Electronic communications, regular research seminars, retreats and shared common resources are used to foster interactions and collaborations among faculty. Because the Center will focus on stress as an etiological factor, rather than on a specific disease, it promises to be an ideal mechanism for understanding and developing new treatments for diverse medical and behavioral disorders. Like the previous K02 award, the K05 award will promote future career development by providing stable salary support and flexibility to enhance technical skills and conceptual bases and promoting leadership.
描述(申请人摘要):这是一份高级科学家的提案

项目成果

期刊论文数量(0)
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RITA VALENTINO其他文献

RITA VALENTINO的其他文献

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{{ truncateString('RITA VALENTINO', 18)}}的其他基金

Modulation of norepinephrine by cannabinoids
大麻素对去甲肾上腺素的调节
  • 批准号:
    8994599
  • 财政年份:
    2005
  • 资助金额:
    $ 12.55万
  • 项目类别:
Bladder Regulation by Corticotropin-Releasing Factor
促肾上腺皮质激素释放因子对膀胱的调节
  • 批准号:
    6964946
  • 财政年份:
    2005
  • 资助金额:
    $ 12.55万
  • 项目类别:
Bladder Regulation by Corticotropin-Releasing Factor
促肾上腺皮质激素释放因子对膀胱的调节
  • 批准号:
    7140376
  • 财政年份:
    2005
  • 资助金额:
    $ 12.55万
  • 项目类别:
BIOGENIC AMINE SYSTEMS, CRF, AND STRESS
生物胺系统、CRF 和压力
  • 批准号:
    6228975
  • 财政年份:
    2001
  • 资助金额:
    $ 12.55万
  • 项目类别:
BIOGENIC AMINE SYSTEMS, CRF, AND STRESS
生物胺系统、CRF 和压力
  • 批准号:
    6863718
  • 财政年份:
    2001
  • 资助金额:
    $ 12.55万
  • 项目类别:
BIOGENIC AMINE SYSTEMS, CRF, AND STRESS
生物胺系统、CRF 和压力
  • 批准号:
    6711708
  • 财政年份:
    2001
  • 资助金额:
    $ 12.55万
  • 项目类别:
BIOGENIC AMINE SYSTEMS, CRF, AND STRESS
生物胺系统、CRF 和压力
  • 批准号:
    6530807
  • 财政年份:
    2001
  • 资助金额:
    $ 12.55万
  • 项目类别:
CORTICOTROPIN RELEASING FACTOR/SEROTONERGIC INTERACTIONS
促肾上腺皮质激素释放因子/血清素相互作用
  • 批准号:
    2757947
  • 财政年份:
    1998
  • 资助金额:
    $ 12.55万
  • 项目类别:
CORTICOTROPIN-RELEASING FACTOR-SEROTONIN INTERACTIONS
促肾上腺皮质激素释放因子-血清素相互作用
  • 批准号:
    6994444
  • 财政年份:
    1998
  • 资助金额:
    $ 12.55万
  • 项目类别:
BRAIN/PELVIC VISCERA INTERACTIONS IN PSYCHIATRIC DISEASE
精神疾病中大脑/盆腔内脏的相互作用
  • 批准号:
    2688701
  • 财政年份:
    1998
  • 资助金额:
    $ 12.55万
  • 项目类别:

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