CANCER EPIDEMIOLOGY IN ADVENTISTS--A LOW RISK GROUP

复临信徒的癌症流行病学——低风险群体

• 批准号: 6656875
• 负责人: GARY E. FRASER
• 金额: $ 410.42万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656875
• 关键词: African American; body physical activity; breast neoplasms; calcium; cancer risk; caucasian American; clinical research; colon neoplasms; dietary lipid; flavones; folate; human subject; meat; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related tag; prostate neoplasms; religious group; soybeans; tomato; vegetables

This application describes a planned cohort study of 80,000 white and 45,000 black adult Seventh-day Adventists, enrolled from across the U.S. Questions not easily addressed by other study populations, can be answered. Taking advantage of the unusual dietary habits of Adventists, the special focus of this application is an association between soy intake, calcium intake, and cancers of the breast, prostate and colon. About half of black and white Adventists consume similar quantities of soy to that used in China or Singapore. Adventists also have a wide variance in intake of calcium. The increasing use of soy and calcium supplements by the American population needs further evidential support. Another strength of the proposed research is the proven ability to enroll and follow a large and cooperative cohort of black Adventists. The very high incidence and mortality ascribed to prostate cancer in black men may be associated with their dietary habits. Subjects will be enrolled church by church using a pretested plan whereby institutional media and respected members at individual churches promote the study. Subjects will complete a comprehensive questionnaire which is already developed and pretested. Cancer surveillance during follow-up will be by matching with state tumor registries where possible, matching with the National Death Index, and by obtaining and coding hospitalization records as necessary. Calibration studies in both black and white Adventists will allow bias correction. We believe that it is important to also gather blood, urine and subcutaneous fat from the subjects, and have a largely pretested plan to accomplish this. This will be further tested for feasibility at a location away from Loma Linda during Year 0 1 of the present study. The Adventist population has been cooperative with epidemiologic research for many years and has some unusual strengths as a research population, including the virtual absence of confounding by tobacco and alcohol, the wide range of dietary habits and the widespread use of soy products. They have made important contributions to the understanding of diet and chronic disease in the past. This larger study will provide much greater statistical power, more accurate and documented exposure assessment, and will also include a large cohort of black Adventists.

该应用程序描述了一项计划的队列研究，对来自美国各地的80,000名白人和45,000名黑人成人的基督复临安息日会，可以回答其他研究人群的问题。利用了复临人的异常饮食习惯，该应用的特别重点是大豆摄入量，钙摄入量和乳腺癌，前列腺和结肠的癌症之间的关联。在中国或新加坡使用的黑人基督复临安息日会中约有一半的大豆消耗了类似的大豆。基督复临信徒在钙的摄入量方面也有很大差异。美国人群对大豆补充剂的日益使用需要进一步的证据支持。拟议的研究的另一个优势是，有经验的能力能够参加并跟随大型且合作的黑人基督复临安息日会。黑人男性的前列腺癌的发病率和死亡率很高，可能与他们的饮食习惯有关。受试者将通过教会招收教会，使用一个预先的计划，从而使机构媒体和尊敬的各个教会成员促进了这项研究。受试者将填写一份已经开发和测试的全面问卷。随访期间的癌症监测将是与州肿瘤注册处匹配，与国家死亡指数匹配，并根据需要获得和编码住院记录。黑人和白色复临人的校准研究将允许校正。我们认为，从受试者那里收集血液，尿液和皮下脂肪也很重要，并在很大程度上有预测的计划来实现这一目标。在本研究的第0年，这将进一步测试在距离洛马·琳达（Loma Linda）的位置的可行性。复临人群多年来一直与流行病学研究合作，并且作为研究人群具有异常的优势，包括烟草和酒精的混杂，多种饮食习惯以及广泛使用大豆产品的混杂。他们过去曾对对饮食和慢性疾病的理解做出了重要贡献。这项更大的研究将提供更大的统计能力，更准确和有记录的暴露评估，还将包括大量的黑人复临人群。