CANCER EPIDEMIOLOGY IN ADVENTISTS--A LOW RISK GROUP

复临信徒的癌症流行病学——低风险群体

• 批准号: 7620322
• 负责人: GARY E. FRASER
• 金额: $ 5万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7620322
• 关键词: Acids; Address; Adipose tissue; Adolescent; Affect; African American; American; Arachidonic Acids; Area; Aspirate substance; Behavior; Biological; Biological Markers; Biology; Blood; Breast; Calcium; Calcium-Sensing Receptors; Calibration; Canada; Collection; Colon; Computers; Consumption; Dairy Products; Data; Development; Diet; Diet Modification; Dietary Assessment; Dietary intake; ESR1 gene; ESR2 gene; Eating; Eicosanoid Production; Enrollment; Ensure; Erythrocytes; Estrogen Receptors; Etiology; Far East; Fatty Acids; Fatty acid glycerol esters; Funding; Genes; Genetic; Genetic Polymorphism; Genus Cola; Goals; Gonadal Steroid Hormones; Grant; Haplotypes; Hormone replacement therapy; Incidence; Inflammation; Inflammatory; Intake; Investigation; Isoflavones; Joints; Lead; Linoleic Acids; Linolenic Acids; Liquid substance; Malignant Neoplasms; Malignant neoplasm of prostate; Mediating; Methods; Minority; Modification; Nitrogen; Nuts; Oncogenes; PTGS2 gene; Phytoestrogens; Plasma; Population; Procedures; Process; Prostate; Proteins; Purpose; Range; Receptor Gene; Registries; Research; Research Personnel; Resources; Risk; Saliva; Sample Size; Sampling; Saturated Fatty Acids; Seeds; Seventh-Day Adventist; Site; Sun Exposure; Sunlight; Testing; Tissues; Unsaturated Fatty Acids; Update; Vitamin D; Vitamin D3 Receptor; Work; cancer epidemiology; cancer risk; cohort; cyclooxygenase 2; cysteine rich protein; daidzein; eicosanoid metabolism; experience; genetic variant; insight; interest; malignant breast neoplasm; men; named group; performance site; repository; soy; soy protein isolate; subcutaneous; trend; tumor; urinary; validation studies

EXCEEDTHESPACE The goals of this research are to provide strong evidence about the possible effects of certain dietary variables on risks of three of the most common cancers (breast, prostate and colon). The selected dietary variables are of great interest as the popular press widely promotes their use, but without clear evidence. They are a) soy isoflavones; b) vitamin D, calcium intake and sunlight exposure; and c) Long chain unsaturated fatty acids (especially linolenic acid). We take the opportunity to study a special population that will add unusual clarity to these investigations. During Years 01-04 of this research a large cohort of Seventh-day Adventists has been established (85,000 of the anticipated 105,000 subjects are now enrolled). More than half of Adventists eat soy at levels seen elsewhere only in the Far East, and estimates of soy intake correlate highly with urinary isoflavones. They also have an unusually wide range of calcium consumption, and the population, who are drawn from all 50 states and Canada, spans of wide range of latitudes and hence sunlight exposure. Nearly half of the population are vegetarian, and many eat dairy products, nuts, seeds and soy, these providing a wide range of dietary linolenic and other long-chain unsaturated acids. These attributes lend power to statistical analyses. A large calibration/validation study of 1000 subjects is being established to support these analyses. During the next 5 years approximately 1650 new cancers at the selected body sites will be identified. With support from the North American tumor registry association, we will computer-match with all U.S and Canadian tumor registries using methods that are uniform and pilot-tested. This has not previously been accomplished and our methods and experience will be useful for other investigators. A new research emphasis in the next funding period is the modification of dietary effects on these cancers, by genes. This work will focus on genetic variants of known functional importance that are relevant to one of the three areas of dietary emphasis listed above. Starting Year 06 four very experienced investigators will collaborate with the Loma Linda research team for this purpose. Using a well-tested plan we will establish a bio-repository to support this new emphasis. Blood will be obtained from 50,000 subjects, subcutaneous fat aspirates from 33,000 and saliva samples from 30,000. At least one biomarker will be obtained from more than 80,000 subjects. Finally, 25-30% of this cohort are black (African-American), and the research questions will be investigated in the whole population as well as separately in this group. Black Adventists have broadly similar dietary trends, but for unknown reasons this minority population has a much greater incidence certain cancers. In summary, we have established a large cohort spanning both the U.S. and Canada from a uniquely informative population. As originally planned it is during the coming Years 06-10 that this outstanding resource will provide answers to the questions posed. PERFORMANCE SITE ========================================Section End===========================================

这项研究的目的是提供强有力的证据，说明某些饮食变量对三种最常见癌症（乳腺癌、前列腺癌和结肠癌）风险的可能影响。选定的饮食变量是非常感兴趣的，因为大众媒体广泛推广他们的使用，但没有明确的证据。它们是a）大豆异黄酮; B）维生素D、钙摄入量和阳光照射;和c）长链不饱和脂肪酸（特别是亚麻酸）。我们借此机会研究一个特殊的人群，这将为这些调查增加不同寻常的清晰度。在本研究的01-04年期间，建立了一个大型的基督复临安息日会队列（预计105，000名受试者中有85，000名现已入组）。超过一半的基督复临安息日会信徒食用大豆的水平仅在远东其他地方可见，大豆摄入量的估计与尿中的胆固醇高度相关。他们的钙摄入量范围也异常广泛，而且人口来自全美50个州和加拿大，纬度范围很广，因此阳光照射也很广。近一半的人口是素食主义者，许多人吃乳制品，坚果，种子和大豆，这些提供了广泛的膳食亚麻酸和其他长链不饱和酸。这些属性为统计分析提供了力量。正在建立一个包含1000名受试者的大型校准/验证研究，以支持这些分析。在未来5年内，将在选定的身体部位确定约1650种新的癌症。在北美肿瘤登记协会的支持下，我们将使用统一和试点测试的方法与所有美国和加拿大肿瘤登记处进行计算机匹配。这是以前没有完成的，我们的方法和经验将对其他研究人员有用。下一个资助期的一个新的研究重点是通过基因改变饮食对这些癌症的影响。这项工作将集中在已知的功能重要性的遗传变异，是相关的三个领域的饮食重点以上列出。从06年开始，四名经验丰富的研究人员将为此目的与洛马琳达研究团队合作。使用一个经过充分测试的计划，我们将建立一个生物储存库，以支持这一新的重点。将从50，000名受试者中采集血液，从33，000名受试者中采集皮下脂肪抽吸物，并从30，000名受试者中采集唾液样本。将从超过80，000例受试者中获得至少一种生物标志物。最后，这个队列中有25-30%是黑人（非洲裔美国人），研究问题将在整个人群中进行调查，并在该组中单独进行调查。黑人基督复临安息日会教徒有着大致相似的饮食趋势，但由于未知的原因，这一少数群体的某些癌症发病率要高得多。总之，我们已经建立了一个大型队列横跨美国和加拿大从一个独特的信息量的人口。正如最初计划的那样，在未来的06-10年，这一杰出的资源将为所提出的问题提供答案。性能现场=