Biomagnetic Signals of Intestinal Ischemia

肠缺血的生物磁信号

• 批准号: 6698016
• 负责人: WILLIAM O RICHARDS
• 金额: $ 31.94万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6698016
• 关键词: arrhythmia; biomagnetism measurement; cellular polarity; clinical research; electrodes; electrophysiology; gastrointestinal circulation; gastrointestinal circulation disorder; gastrointestinal motility /pressure; gastrointestinal surgery; human subject; ischemia; laboratory rabbit; magnetic field; mathematical model; mesenteric artery; mesentery; model design /development; noninvasive diagnosis; patient oriented research; superconductivity

DESCRIPTION (Provided by Applicant): Intestinal ischemia whether resulting from emboli, thrombosis or strangulation obstruction continues to be a serious and potentially fatal condition. We have pioneered the use of Superconducting Quantum Interference Device (SQUID) magnetometers for biomagnetic recordings of gastrointestinal smooth muscle activity in vitro, and in both animal and human subjects. This non-invasive, non-contact measurement of biomagnetic currents in smooth muscle demonstrates the feasibility of using SQUIDs to investigate human intestinal smooth muscle physiology. SQUIDs have unique fundamental advantages over cutaneous electrode recordings of intestinal electrical activity because magnetic fields readily penetrate layers of fat while electrical fields do not and cutaneous electrode recordings of human small bowel can not be routinely obtained. SQUIDs represent a striking new diagnostic device that has no equivalent except for invasive surgery and placement of electrodes onto the bowel surface. Hypothesis 1: Mesenteric ischemia causes uncoupling and arrhythmias of intestinal smooth muscle detectable in externally recorded magnetic fields. We will develop models to explain the arrhythmias, uncoupling and the effects of intervening tissue on the externally recording magnetic fields. Advanced analysis techniques to discriminate ischemic bowel from normal signals will be developed base upon our knowledge of smooth muscle behavior during ischemia. We will characterize for the fist time the magnetic currents in recordings taken during and after surgical exploration. Hypothesis w: Mesenteric ischemia causes sustained polarization of affected smooth muscle cells resulting in injury currents detectable in the externally recorded magnetic fields. Injury currents have been previously demonstrated to occur and be detectable magnetically in cardiac animal and human studies to detect this phenomenon. The new multichanel SQUID specifically designed for study of human intestinal magnetic fields developed and built as part of a SBIR grant will be available for use and will give us an extraordinary opportunity for the first time to explore smooth muscle pathophysiology during intestinal ischemia-one of the most deadly diseases known to man.

描述（由申请人提供）：肠缺血，无论是由 栓塞、血栓形成或绞窄性梗阻仍然是严重的， 可能致命的情况我们率先使用超导 量子干涉仪（SQUID）磁强计，用于生物磁记录 胃肠平滑肌活性在体外，并在动物和人类 科目这种非侵入性，非接触式测量生物磁电流， 平滑肌证明了使用SQUID研究人类的可行性 肠平滑肌生理学SQUID具有独特的基本优势 肠电活动的皮肤电极记录，因为 磁场很容易穿透脂肪层，而电场则不能 并且人体小肠的皮肤电极记录不能常规地 得到了SQUID代表了一种引人注目的新诊断设备， 等同，但侵入性手术和将电极放置在 肠表面。假设1：肠系膜缺血导致解偶联， 肠平滑肌的心律失常检测在外部记录 磁场我们将开发模型来解释心律失常， 以及介入组织对外部记录磁信号的影响 领域的先进的分析技术区分缺血性肠和正常肠 信号将基于我们对平滑肌行为的了解而产生 在局部缺血期间。我们将首次描述磁流的特征 在手术探查期间和之后的记录中。假设W： 肠系膜缺血导致受累平滑肌持续极化 细胞，导致在外部记录的 磁场先前已证明会发生损伤电流， 在心脏动物和人类研究中可通过磁性检测到 现象新的多通道SQUID专门设计用于研究人类 作为SBIR赠款的一部分开发和建立的肠道磁场 将可供使用，并将给我们一个非凡的 首次有机会探索平滑肌病理生理学， 肠缺血-人类已知的最致命的疾病之一。