Biomagnetic Signals of Intestinal Ischemia

肠缺血的生物磁信号

• 批准号: 6849245
• 负责人: WILLIAM O RICHARDS
• 金额: $ 31.94万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6849245
• 关键词: arrhythmia; biomagnetism measurement; cellular polarity; clinical research; electrodes; electrophysiology; gastrointestinal circulation; gastrointestinal circulation disorder; gastrointestinal motility /pressure; gastrointestinal surgery; human subject; ischemia; laboratory rabbit; magnetic field; mathematical model; mesenteric artery; mesentery; model design /development; noninvasive diagnosis; patient oriented research; superconductivity

DESCRIPTION (Provided by Applicant): Intestinal ischemia whether resulting from emboli, thrombosis or strangulation obstruction continues to be a serious and potentially fatal condition. We have pioneered the use of Superconducting Quantum Interference Device (SQUID) magnetometers for biomagnetic recordings of gastrointestinal smooth muscle activity in vitro, and in both animal and human subjects. This non-invasive, non-contact measurement of biomagnetic currents in smooth muscle demonstrates the feasibility of using SQUIDs to investigate human intestinal smooth muscle physiology. SQUIDs have unique fundamental advantages over cutaneous electrode recordings of intestinal electrical activity because magnetic fields readily penetrate layers of fat while electrical fields do not and cutaneous electrode recordings of human small bowel can not be routinely obtained. SQUIDs represent a striking new diagnostic device that has no equivalent except for invasive surgery and placement of electrodes onto the bowel surface. Hypothesis 1: Mesenteric ischemia causes uncoupling and arrhythmias of intestinal smooth muscle detectable in externally recorded magnetic fields. We will develop models to explain the arrhythmias, uncoupling and the effects of intervening tissue on the externally recording magnetic fields. Advanced analysis techniques to discriminate ischemic bowel from normal signals will be developed base upon our knowledge of smooth muscle behavior during ischemia. We will characterize for the fist time the magnetic currents in recordings taken during and after surgical exploration. Hypothesis w: Mesenteric ischemia causes sustained polarization of affected smooth muscle cells resulting in injury currents detectable in the externally recorded magnetic fields. Injury currents have been previously demonstrated to occur and be detectable magnetically in cardiac animal and human studies to detect this phenomenon. The new multichanel SQUID specifically designed for study of human intestinal magnetic fields developed and built as part of a SBIR grant will be available for use and will give us an extraordinary opportunity for the first time to explore smooth muscle pathophysiology during intestinal ischemia-one of the most deadly diseases known to man.

描述（由申请人提供）：肠缺血是否由以下原因引起 栓塞、血栓形成或绞窄性梗阻仍然是一个严重且 可能致命的情况。我们率先使用超导 用于生物磁记录的量子干涉装置 (SQUID) 磁力计 体外、动物和人类胃肠道平滑肌活性 科目。这种非侵入式、非接触式的生物磁电流测量 平滑肌展示了使用 SQUID 来研究人类的可行性 肠道平滑肌生理学。 SQUIDs具有独特的基本优势 通过皮肤电极记录肠道电活动，因为 磁场很容易穿透脂肪层，而电场则不然 人体小肠的皮肤电极记录不能常规进行 获得。 SQUID 代表了一种引人注目的新型诊断设备，它没有 除了侵入性手术和将电极放置在 肠表面。假设1：肠系膜缺血导致解偶联和 在外部记录中可检测到肠平滑肌心律失常 磁场。我们将开发模型来解释心律失常、解耦 以及介入组织对外部记录磁的影响 字段。先进的分析技术可区分缺血性肠和正常肠 信号将根据我们对平滑肌行为的了解而开发 缺血期间。我们将首次表征磁流 在手术探查期间和之后进行的录音。假设w： 肠系膜缺血导致受影响的平滑肌持续极化 细胞导致损伤电流可在外部记录中检测到 磁场。损伤电流先前已被证明会发生并且 在心脏动物和人类研究中可通过磁性检测来检测这一点 现象。专为人类研究而设计的新型多通道 SQUID 作为 SBIR 资助的一部分开发和建造的肠道磁场 将可供使用并将给我们带来非凡的 首次有机会探索平滑肌病理生理学 肠道缺血——人类已知的最致命的疾病之一。