Biomagnetic Signals of Intestinal Ischemia

肠缺血的生物磁信号

• 批准号: 7479751
• 负责人: WILLIAM O RICHARDS
• 金额: $ 26.95万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479751
• 关键词: Abbreviations; Abdomen; Abdominal Cavity; Acute; Affect; Animals; Area; Arrhythmia; Bradyarrhythmias; Cardiac; Cells; Characteristics; Chronic; Clinical; Clinical Research; Colon; Coupling; Cutaneous; Data; Detection; Development; Diagnostic; Disease; Early Diagnosis; Early treatment; Electrocardiogram; Electrodes; Electromagnetic Fields; Electromagnetics; Electromyography; Electrophysiology (science); Environment; Fascia; Fatty acid glycerol esters; Fourier Transform; Frequencies; Genus Cola; Geum; Goals; Health; Heart; Hospitals; Human; Human Volunteers; Image; Intestines; Ischemia; Ischemic Bowel Disease; Knowledge; Laboratories; Laboratory Study; Large Intestine; Light; Localized; Magnetometries; Mesenteric Arteries; Mesentery; Methods; Modality; Modeling; Morbidity - disease rate; Muscle; Omentum; Operating Rooms; Operative Surgical Procedures; Pathology; Patients; Pattern; Physicians; Physiological; Physiological reperfusion; Physiology; Postoperative Period; Regulation; Relaxation; Reperfusion Injury; Reperfusion Therapy; Research; Research Personnel; Serous Membrane; Signal Transduction; Skin; Small Intestines; Smooth Muscle; Smooth Muscle Myocytes; Source; Squid; Stomach; Surface; Surgical sutures; Tachyarrhythmias; Techniques; Technology; Time; Tissues; Universities; Veins; abdominal wall; attenuation; density; egg; electrical potential; electrical property; extracellular; gastrointestinal; human subject; implantation; improved; interest; magnetic field; mortality; programs; response; spatiotemporal; superconducting quantum interference device

DESCRIPTION (provided by applicant): Many patients suffer from illnesses that relate to disturbances in the electrical activity of the small intestine, however efforts to investigate these problems in human subjects have been thwarted because currently available electrode technology require surgical implantation and are not accepted by patients nor their physicians. In recent years, biomagnetic imaging methods have, for the first time, facilitated the noninvasive assessment of the intestinal slow wave activity in human subjects. Animal studies have confirmed that transabdominal magnetic fields of the magnetoenterogram (MENG) accurately reflect the internal intestinal slow wave frequency and the spatial frequency gradient. We have established and are currently using new hospital facility, the Vanderbilt University Gastrointestinal SQUID Technology (VU-GIST) Laboratory study the pathological effects of chronic mesenteric ischemia on the slow wave. We are poised to continue our ground-breaking contributions to the physiological and pathophysiological implications of the activity the intestinal slow wave in patients with chronic mesenteric ischemia. We propose to advance these by continuing to develop the recording and analysis techniques that will allow us to differentiate and distinguish the multiple contributions to the biomagnetic field from different parts of the small intestine from other corporeal sources such as colonic electrical activity. We will examine the effect of partial near total occlusion of the mesenteric vessels on the MENG signal as a model of chronic ischemia. We will smaller segments of ischemic bowel to determine the ability of current analysis techniques to identify localized ischemia noninvasively and to develop more advanced techniques for this analysis. We will our initial animal studies that have provided convincing evidence that the MENG reflects the underlying pathological slow wave to pre-, intra- and post-operative studies of human patients with chronic mesenteric ischemia, and we will analyze the biomagnetic fields obtained in these studies to assess the spatiotemporal signatures of intestinal slow waves during ischemia and reperfusion. The ultimate goal of this project is to develop the SQUID into a noninvasive diagnostic modality for patients with mesenteric ischemia.

描述（由申请人提供）：许多患者患有与小肠电活动紊乱相关的疾病，然而，在人类受试者中研究这些问题的努力受到了阻碍，因为目前可用的电极技术需要手术植入，并且不被患者及其医生接受。近年来，生物磁成像方法，第一次，促进了人体肠道慢波活动的无创评估。动物实验已经证实，经腹磁肠图（MENG）的磁场准确地反映了内部肠道慢波频率和空间频率梯度。我们已经建立并正在使用新的医院设施，范德比尔特大学胃肠道SQUID技术（VU-GIST）实验室研究慢性肠系膜缺血对慢波的病理影响。我们准备继续对慢性肠系膜缺血患者肠慢波活动的生理和病理生理意义做出突破性贡献。我们建议通过继续开发记录和分析技术来推进这些，这些技术将使我们能够区分和区分来自小肠不同部分的生物磁场的多种贡献，以及来自其他皮质来源的生物磁场，如结肠电活动。我们将研究肠系膜血管部分接近完全闭塞对MENG信号的影响，作为慢性缺血模型。我们将更小的缺血肠段，以确定目前的分析技术的能力，以确定局部缺血非侵入性和发展更先进的技术，这种分析。我们将我们最初的动物研究，提供了令人信服的证据，MENG反映了潜在的病理性慢波的术前，术中和术后的研究与慢性肠系膜缺血的人类患者，我们将分析在这些研究中获得的生物磁场，以评估在缺血和再灌注肠慢波的时空签名。该项目的最终目标是将SQUID发展为肠系膜缺血患者的非侵入性诊断模式。