Biomagnetic Signals of Intestinal Ischemia

肠缺血的生物磁信号

• 批准号: 6720669
• 负责人: WILLIAM O RICHARDS
• 金额: $ 25.2万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6720669
• 关键词: Biomagnetic; Signals; Intestinal; Ischemia

DESCRIPTION (provided by applicant): Intestinal ischemia whether resulting from emboli, thrombosis or strangulation obstruction continues to be a serious and potentially fatal condition. We have pioneered the use of Superconducting Quantum Interference Device (SQUID) magnetometers for biomagnetic recordings of gastrointestinal smooth muscle activity in vitro, and in both animal and human subjects. This non-invasive, non-contact measurement of biomagnetic currents in smooth muscle demonstrates the feasibility of using SQUIDs to investigate human intestinal smooth muscle physiology. SQUIDs have unique fundamental advantages over cutaneous electrode recordings of intestinal electrical activity because magnetic fields readily penetrate layers of fat while electrical fields do not and cutaneous electrode recordings of human small bowel can not be routinely obtained. SQUIDs represent a striking new diagnostic device that has no equivalent except for invasive surgery and placement of electrodes onto the bowel surface. Hypothesis 1: Mesenteric ischemia causes uncoupling and arrhythmias of intestinal smooth muscle detectable in externally recorded magnetic fields. We will develop models to explain the arrhythmias, uncoupling and the effects of intervening tissue on the externally recording magnetic fields. Advanced analysis techniques to discriminate ischemic bowel from normal signals will be developed base upon our knowledge of smooth muscle behavior during ischemia. We will characterize for the fist time the magnetic currents in recordings taken during and after surgical exploration. Hypothesis w: Mesenteric ischemia causes sustained polarization of affected smooth muscle cells resulting in injury currents detectable in the externally recorded magnetic fields. Injury currents have been previously demonstrated to occur and be detectable magnetically in cardiac animal and human studies to detect this phenomenon. The new multichanel SQUID specifically designed for study of human intestinal magnetic fields developed and built as part of a SBIR grant (NIH R44 DK49435-2) will be available for use and will give us an extraordinary opportunity for the first time to explore smooth muscle pathophysiology during intestinal ischemia-one of the most deadly diseases known to man.

描述（由申请人提供）： 肠缺血，无论是由栓子、血栓形成还是绞窄性梗阻引起，仍然是一种严重的和潜在的致命性疾病。我们率先使用超导量子干涉器件（SQUID）磁强计进行体外胃肠道平滑肌活动的生物磁记录，以及动物和人类受试者。这种非侵入性，非接触测量平滑肌中的生物磁电流证明了使用SQUID研究人类肠道平滑肌生理学的可行性。SQUID与肠电活动的皮肤电极记录相比具有独特的基本优势，因为磁场容易穿透脂肪层，而电场不能，并且不能常规获得人类小肠的皮肤电极记录。SQUID代表了一种引人注目的新诊断设备，除了侵入性手术和将电极放置在肠表面之外，没有等同设备。假设1：肠系膜缺血导致解偶联和心律失常的肠平滑肌检测外部记录磁场。我们将开发模型来解释心律失常，解耦和干预组织对外部记录磁场的影响。先进的分析技术，以区分缺血肠正常信号将开发基于我们的知识，在缺血期间的平滑肌行为。我们将首次描述手术探查期间和手术探查后记录中的磁电流。假设W：肠系膜缺血导致受影响的平滑肌细胞持续极化，导致在外部记录的磁场中可检测到的损伤电流。损伤电流先前已被证明会发生，并在心脏动物和人类研究中可磁性检测到，以检测这种现象。新的多通道SQUID专门设计用于研究人类肠道磁场的开发和建立作为SBIR赠款（NIH R44 DK 49435 -2）的一部分，将可供使用，并将首次为我们提供一个非凡的机会来探索肠道缺血期间的平滑肌病理生理学-人类已知的最致命的疾病之一。