HEMISPERIC: SPECIALIZATION AND INTERACTION

描述：（改编自研究者摘要） 拟议中的研究计划旨在揭开持续存在的神秘面纱 大脑半球的特化和大脑半球间的相互作用 头脑/大脑。我们将与正常受试者进行协调实验， 大脑半球受损患者和裂脑患者，使用会聚 行为和生理学方法。该方案解决了一般问题， 认知神经科学涉及模块化，模块间通信， 在独立模块中控制并行处理。 一组核心的三个侧化行为实验将调查（1） 大脑半球的专业化和相互依存，（2）显性和隐性 大脑半球间的转移，（3）平行的大脑半球间的控制 处理.每个实验范例都包括一个半球内的组件 用于研究半球独立性，以及半球间成分， 研究大脑半球间的相互作用和控制同样的行为 实验将对患有（1）完全脑梗死的患者进行， 连合切开术，（2）胼胝体发育不全，和（3）部分 胼胝体切开术，包括手术前和手术后。 第一种模式是分听单词和口音。它测量 语言语音分析的左半球互补特化 和右半球的社会/务实方面的专业化 通信第二个范式是侧化目标的词汇决定 在相反的半视野中有干扰物。它测量独立的词 识别，两个半球的独立错误监控，以及内隐 大脑半球的启动。第三种范式是知觉匹配 字母的形状或名称内和之间的半球。它测量 大脑半球在复杂任务中并行处理信息的能力。 总之，本提案中开发的三个实验范式提供了一个 紧凑但全面，灵敏度高的电池测试， 大脑半球间的关系这种电池可以用来学习 在正常人和正常人中， 病理人群，如后天性失语症，先天性阅读障碍， 精神分裂症结果保证了更好的理解和可能的控制， 由于异常脑激活或受损而导致的病理逆转 大脑半球间的交流

DESCRIPTION: (Adapted from the Investigator's Abstract) The proposed research program aims to unravel the persisting mystery of hemispheric specialization and interhemispheric interaction in the human mind/brain. We will carry out coordinated experiments with normal subjects, hemisphere damaged patients, and split brain patients, using convergent behavioral and physiological methods. The program addresses general issues in cognitive neuroscience concerning modularity, intermodular communication, and control of parallel processing in independent modules. A core set of three lateralized behavioral experiments will investigate (1) hemispheric specialization and interdependence, (2) explicit and implicit interhemispheric transfer, and (3) interhemispheric control of parallel processing. Each experimental paradigm includes an intrahemispheric component for studying hemispheric independence, and an interhemispheric component for studying interhemispheric interaction and control. The same behavioral experiments will be administered to patients with (1) complete cerebral commissurotomy, (2) agenesis of the corpus callosum, and (3) partial callosotomy, both pre- and post-surgically. The first paradigm is dichotic listening to words and accents. It measures complementary left hemispheric specialization for linguistic phonetic analysis and right hemisphere specialization for social/pragmatic aspects of communication. The second paradigm is lexical decision of lateralized targets with distractors in the opposite visual hemifield. It measures independent word recognition, independent error monitoring in the two hemispheres, and implicit priming across the hemispheres. The third paradigm is perceptual matching of letters by shape or by name within and between the hemispheres. It measures the ability of the hemispheres to process information in parallel in complex tasks. Together, the three experimental paradigms developed in this proposal provide a compact but comprehensive and exquisitely sensitive battery of tests of interhemispheric relations. This battery can then be used for studying individual or group differences in interhemispheric relations in normal and pathological populations, such as acquired aphasia, congenital dyslexia and schizophrenia. Results promise better understanding and possible control and reversal of pathology due to abnormal cerebral activation or impaired interhemispheric communication.