HEMISPHERIC SPECIALIZATION AND INTERHEMISPHERIC RELATIONS: LANGUAGE

半球特化和半球间关系：语言

• 批准号: 6283225
• 负责人: ERAN ZAIDEL
• 金额: $ 1.27万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6283225
• 关键词: biomedical resource; cognition; communication behavior; computers; magnetic resonance imaging; model design /development; nervous system; nuclear magnetic resonance spectroscopy; statistics /biometry

This proposal is part of a research program that aims to clarify (1) hemispheric specialization and independence. (2) interhemispheric spheric interaction, and (3) interhemispheric control. These mechanisms of interhemispheric relations address three central theoretical concepts in cognitive neuroscience: modularity of processing. intermodular communication. and behavior. Specific Aims A basic thesis of this research program is that the two cerebral hemispheres constitute parallel, semi-independent. information processing systems which interact through function-specific cortical channels in the corpus and through less specific subcortical channels. In the following proposal we analyze the anatomical basis of the relationship between hemispheric specialization and interhemispheric interaction by analyzing the anatomical substrates of language gifted asymmetric cortex and of the callosal channels that interconnect it. We focus on two regions corresponding to two of our main behavioral tasks; Broca's area, which is specialized for phonetic processing in dichotic listening to nonsense consonant-vowel syllables (CVs) and; Wernicke's area, which is specialized for lateralized lexical decision. Since we believe that the different behavioral measures draw upon these different cortical regions, we hypothesize that different behavioral measures will also be associated with different callosal channels. Furthermore, we expect the anatomical asymmetry of cortical modules will be negatively correlated with the size of the callosal channel that interconnects it. Another goal is to map the organization of callosal channels and their relationship to hemispheric specialization.

这项提议是一项研究计划的一部分，该计划旨在阐明 (1)半球的专业化和独立性。 (2)半球间 球面相互作用;（3）半球间控制。 这些 大脑半球间关系的机制涉及三个中心 认知神经科学的理论概念： 处理. 模块间通信 和行为。 具体目标 这项研究计划的一个基本论点是， 半球构成平行，半独立。 信息 处理系统通过特定功能的皮层 通道在身体和通过不太具体的皮层下通道。 在下面的建议中，我们分析了 半球特化与半球间的关系 通过分析语言天才的解剖学基础， 不对称的皮质和互连皮质的胼胝体通道。 我们集中在两个区域对应于我们的两个主要行为 布罗卡区，专门用于语音处理， 分听无意义的辅音-元音音节（CV）; 韦尼克区，专门负责侧化词汇 决定 因为我们相信不同的行为指标 这些不同的皮层区域，我们假设， 行为测量也将与不同的胼胝体 渠道 此外，我们预计皮质的解剖不对称性 模块将与胼胝体的大小呈负相关 另一个目标是绘制 胼胝体通道的组织及其与 半球特化