HEMISPERIC: SPECIALIZATION AND INTERACTION

半球：专业化和互动

• 批准号: 7369376
• 负责人: ERAN ZAIDEL
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369376
• 关键词: HEMISPERIC; SPECIALIZATION; INTERACTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is part of a research program that aims to clarify (1) hemispheric specialization and independence, (2) interhemispheric interaction, and (3) interhemispheric control. These mechanisms of interhemispheric relations address three central theoretical concepts in cognitive neuroscience: modularity of processing, intermodular communication, and control of parallel modular processes. A core set of progressively complex lateralized behavioral paradigms developed in our laboratory have been designed to (1) explore individual differences in hemispheric specialization in attention, perception and language; (2) contrast different degrees of hemispheric independence, including independence strategies, resources and priming, and (3) analyze the control of parallel processing in the two hemispheres. These experiments range from sensorimotor integration in simple reaction time through phonetic perception and letter identification to complex word recognition. Each experimental paradi gm includes an intrahemispheric component for studying hemispheric independence, and an interhemispheric component for studying interhemispheric interaction and control. These experiments have been administered to normal subjects and to patients with complete cerebral commissurotomy, agenesis of the corpus callosum and patients with partial callosotomy both pre- and post surgically as well as with patients with selected lateralized lesions to examine the role of the right hemisphere in natural language processing. This proposal focuses on the study of the anatomical correlates with some of the same above mentioned behavioral measures of interhemispheric relations. With this approach we combine sophisticated cognitive theory and methodology on the one hand, with in-depth neuroscientific analysis that incorporates anatomical, physiological and clinical behavioral techniques, data and theory on the other. Thus, we use converging studies of normal subjects and parallel measures of brain structure (MRI), brain function, and behavior.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这个建议是一个研究计划的一部分，该计划旨在阐明（1）半球的专门化和独立性，（2）半球间的相互作用，（3）半球间的控制。这些大脑半球间关系的机制解决了认知神经科学中的三个核心理论概念：处理的模块化，模块间通信和并行模块化过程的控制。本实验室设计了一套核心的渐进复杂偏侧化行为范式，旨在：（1）探索注意、知觉和语言半球专业化的个体差异;（2）对比不同程度的半球独立性，包括独立性策略、资源和启动;（3）分析两半球平行加工的控制。这些实验的范围从简单反应时的感觉运动整合，通过语音感知和字母识别到复杂的单词识别。每一个实验模型都包括一个用于研究半球独立性的半球内部分和一个用于研究半球间相互作用和控制的半球间部分。这些实验已被管理到正常受试者和患者完全脑commissurotomy，发育不全的胼胝体和患者部分胼胝体切开术前和手术后，以及与选定的偏侧病变的患者检查的作用，右半球在自然语言处理。该建议侧重于研究与上述半球间关系的一些相同行为测量的解剖学相关性。通过这种方法，我们一方面结合了联合收割机复杂的认知理论和方法，另一方面结合了深入的神经科学分析，包括解剖，生理和临床行为技术，数据和理论。因此，我们使用正常受试者的融合研究和大脑结构（MRI），大脑功能和行为的平行测量。