RESEARCH TRAINING IN TRANSLATIONAL TUMOR IMMUNOLOGY

描述(申请人描述)：此申请代表一个新的 关于NCI资助的“翻译研究培训”项目的建议 密歇根大学的《肿瘤免疫学》。 对翻译免疫学的兴趣是从他们的主要 外科、医学、微生物学、化学、病理学、 放射肿瘤学和实验动物医学。这些戒律也是 新的免疫学研究生课程成员和/或综合 癌症中心(CCC)的肿瘤免疫学项目。17项调查中的每一项- 托尔斯领导着一个活跃的实验室，有保护外墙的记录 支持。詹姆斯·J·穆勒博士将担任项目主任，他将 与指导委员会密切合作，挑选受训人员并制定 计划政策。博士前实习生将参加研究生计划 在免疫学方面，它结合了医学院的资源，研究生 学校，和CCC。这些学生将学习生物化学、遗传学、 和免疫学，为他们的论文研究做好准备 训诫。博士后实习生将致力于全日制 研究。拟议的培训方案，通过#年的研究生方案 免疫学和肿瘤免疫学项目将共同赞助四大 活动：a)一个两周一次的期刊俱乐部，学员和讲师在这里见面 关于最近免疫学论文的指导探索；b)每月一次的研讨会 来自其他大学、研究机构、 和行业提供研究数据，并与学员举行一天的会议，并 教员；c)研究性座谈会课程，其主题和讲师各不相同 每学期；它允许研究生(和博士后审计员)阅读 关于并深入讨论现代基础和基础课程的一系列重要主题 翻译免疫学；以及d)每季度由 肿瘤免疫学计划，教职员工在该计划中展示与主题相关的 建立了研究数据和合作努力。研究生 博士后研究员也参加了这些务虚会。该计划包括 研究责任培训和招聘计划 少数群体的代表性不足。请求为四名博士后提供支持 以及每年四名博士后实习生。博士后和博士后 学员应该为专注于学术生涯的课程做好充分准备 关于免疫学研究的翻译方面，因为它与 开发治疗癌症的新策略。

DESCRIPTION (Applicant's Description): This application represents a new proposal for an NCI-sponsored program of "Research Training in Translational Tumor Immunology" at the University of Michigan. Faculty preceptors with interests in translational immunology have been selected from their primary D e p artments of Surgery, Medicine, Microbiology, Chemistry, Pathology, Radiation Oncology, and Laboratory Animal Medicine. These preceptors are also members of the new Graduate Program in Immunology and/or the Comprehensive Cancer Center's (CCC's) Tumor Immunology Program. Each of the 17 investiga- tors directs an active laboratory with a record of securing extramural support. Dr. James J. Mule will serve as the Program Director, and he will work closely with a Steering Committee to select trainees and formulate program policy. Predoctoral trainees will be enrolled in the Graduate Program in Immunology, which combines the resources of the Medical School, Graduate School, and CCC. The students will take courses in biochemistry, genetics, and immunology to prepare them for dissertation research with any of the preceptors. Postdoctoral trainees will devote their effort to full-time research. The proposed training program, through the Graduate Program in Immunology and the Tumor Immunology Program, will co-sponsor four major activities: a) a biweekly journal club at which trainees and preceptors meet for guided explorations of recent immunology papers; b) a monthly seminar series at which invited speakers from other universities, research institutes, and industry present research data and spend a day meeting with trainees and faculty; c) a Research Colloquium course, whose topic and instructor varies each semester; it allows graduate students (and postdoctoral auditors) to read about, and discuss in depth, a series of important topics in modern basic and translational immunology; and d) a scientific retreat held quarterly by the Tumor Immunology Program, at which faculty members present topic-related research data and collaborative efforts are established. Graduate students and postdoctoral fellows attend these retreats also. The program includes plans for training in research responsibility and for recruitment of underrepresented minority groups. Support is requested for four predoctoral and four postdoctoral trainees each year. Predoctoral and postdoctoral trainees should leave the program well prepared for academic careers focused on translational aspects of immunologic research as it pertains to the development of new strategies for the treatment of cancer.