NEURAL MECHANISMS OF VESTIBULAR FUNCTION IN FISH
鱼类前庭功能的神经机制
基本信息
- 批准号:6592815
- 负责人:
- 金额:$ 16.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-04-01 至 2003-03-31
- 项目状态:已结题
- 来源:
- 关键词:Osteichthyes afferent nerve biological signal transduction biomechanics cilium /flagellum motility confocal scanning microscopy dyes ear hair cell electron microscopy electronic stimulator electrophysiology endolymph head movements light microscopy membrane potentials morphology neural information processing perilymph semicircular duct sensory receptors single cell analysis vestibular nerve vestibular pathway vestibuloocular reflex video microscopy voltage /patch clamp
项目摘要
The overall goals of the proposal are to characterize the determinants
of the response dynamics of the horizontal semicircular canal and to
study the mechanisms and sequels of the efferent vestibular systems
manipulation of these determinants. The response dynamics of the
horizontal semicircular canal nerve have been documented in this species.
There are three broad classes of afferent based upon their response
dynamics across the frequency and amplitude spectrum studied. There are
frequency and amplitude dependent non-linearities represented within the
responses of certain classes of afferent. The contributions and
significance of the putative differential motion of the center and
periphery of the cupula and of hair cell receptor current frequency and
amplitude dependent non-linearities to those in the primary afferents
will be evaluated. Whole cell patch clamp techniques will be applied to
hair cells isolated from defined functional regions of the crista to
study the magnitude and kinetics of activation, inactivation, and
deactivation of potassium currents. The current clamp responses to
perturbing currents of these cells will be determined. Differential
efferent action upon the various classes of primary afferent has also
been documented. The implications and mechanisms of this differential
action will be studied with morphological and physiological techniques.
The amplitudes and shapes of miniature (m) EPSPs recorded from primary
afferents will be measured before and during stimulation of efferents to
assess the significance of the efferent evoked changes in EPSP
characteristics to the output of the system. The activation sequelae of
the efferent vestibular system upon horizontal canal afferents in free
swimming fish will be studied utilizing multi-channel electrodes, under
water acoustic telemetry and under water video. Thus, we hope to arrive
at a general theory of efferent action in this species. Studies of the
cellular and systems science aspects of the vestibular system and its
efferent control add information about function and may bear upon
possible future therapies and mechanisms for the control of motion
sickness.
该提案的总体目标是确定决定因素的特征
水平半规管的反应动力学
前庭传出系统的机制及后遗症研究
操纵这些决定因素。的响应动力学。
水平半规管神经已在该物种中被记录。
根据他们的反应,有三大类传入
研究了整个频率和幅度频谱的动力学。确实有
中表示的依赖于频率和幅度的非线性
某些类别的传入反应。这些贡献和
假设的中心和中心的微分运动的意义
毛细胞感受器电流频率和毛细胞的周围
初级传入神经元的幅值相关非线性
将会被评估。全细胞膜片钳技术将应用于
从确定的眉骨功能区分离的毛细胞到
研究激活、失活和
钾电流失活。电流钳位响应
这些电池的扰动电流将被确定。差动
不同类别的初级传入的传出动作也
已被记录在案。这种差异的含义和机制
将用形态和生理技术来研究它们的作用。
从初级记录的微型(M)EPSP的幅度和形状
在刺激传出神经之前和期间将测量传入神经。
评价EPSP传出诱发改变的意义
特性到系统的输出。的激活后遗症
游离传出前庭系统对水平神经管传入的影响
将利用多通道电极研究游动的鱼,在
水声遥测和水下视频。因此,我们希望到达
在这个物种中传出行为的一般理论。对中国传统文化的研究
前庭系统及其相关的细胞和系统科学方面
传出控制添加有关功能的信息,并可能与
未来可能的运动控制疗法和机制
生病了。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stephen Morris Highstein其他文献
Stephen Morris Highstein的其他文献
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{{ truncateString('Stephen Morris Highstein', 18)}}的其他基金
Synaptic Determinants of Vestibular Afferent Dynamics
前庭传入动力学的突触决定因素
- 批准号:
8039125 - 财政年份:2009
- 资助金额:
$ 16.33万 - 项目类别:
Synaptic Determinants of Vestibular Afferent Dynamics
前庭传入动力学的突触决定因素
- 批准号:
8247709 - 财政年份:2009
- 资助金额:
$ 16.33万 - 项目类别:
Synaptic Determinants of Vestibular Afferent Dynamics
前庭传入动力学的突触决定因素
- 批准号:
7799211 - 财政年份:2009
- 资助金额:
$ 16.33万 - 项目类别:
Synaptic Determinants of Vestibular Afferent Dynamics
前庭传入动力学的突触决定因素
- 批准号:
7651556 - 财政年份:2009
- 资助金额:
$ 16.33万 - 项目类别:
Synaptic Determinants of Vestibular Afferent Dynamics
前庭传入动力学的突触决定因素
- 批准号:
7850267 - 财政年份:2009
- 资助金额:
$ 16.33万 - 项目类别:
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