Customized Contact Lenses

定制隐形眼镜

• 批准号: 6670855
• 负责人: GEUNYOUNG YOON
• 金额: $ 26.18万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-02 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6670855
• 关键词: biomedical equipment development; clinical biomedical equipment; clinical research; contact lens; cornea disorder; diagnosis design /evaluation; eye disorder diagnosis; human subject; human therapy evaluation; keratoconus; keratoplasty; optics; patient oriented research

DESCRIPTION (provided by applicant): Wavefront aberrations in the eye's optics degrade vision. These aberrations, including many higher order aberrations that are not corrected by conventional spectacles, are especially severe in patients with keratoconus and in patients who have had penetrating keratoplasty. Accurate measurement and correction of these higher order aberrations could result in substantial improvements in vision. However, little wave aberration data can be obtained from patients with these conditions, primarily because existing wavefront sensors have too small a dynamic range to measure the large aberrations in these eyes. Moreover, even if measurements were available, there are few available therapeutic alternatives. The research objectives of this bioengineering research project are to develop a robust wavefront sensor, with a large dynamic range, that will reliably diagnose the wave aberrations in highly aberrated eyes, and to develop a customized contact lens that can compensate for most of these aberrations. The key to expanding the dynamic range of the wavefront sensor is the use of a translational plate that increases spacing between wavefront sensing spots. The key to developing the contact lens is the use of high-power laser ablation of the contact lens based on the measurements with the wavefront sensor.

描述（由申请人提供）： 眼睛的光学降低视力降低。这些畸变，包括许多未被常规眼镜纠正的高阶畸变，在角膜结构患者中尤其严重，患有穿透性角膜生成形术的患者。准确的测量和校正这些高阶畸变可能会导致视力大大改善。但是，可以从患有这些条件的患者那里获得少量波像差数据，这主要是因为现有的波前传感器的动态范围太小，无法测量这些眼睛中的大畸变。此外，即使可以进行测量，也很少有可用的治疗替代方法。该生物工程研究项目的研究目标是开发具有较大动态范围的稳健波前传感器，该传感器将可靠地诊断出高度差的眼睛中的波浪畸变，并开发自定义的隐形眼镜，以补偿大多数这些像差。扩展波前传感器动态范围的关键是使用翻译板，该平台在波前传感点之间增加了间距。开发隐形眼镜的关键是基于波前传感器的测量结果，使用了隐形眼镜的高功率激光消融。