Customized Contact Lenses

定制隐形眼镜

• 批准号: 6670855
• 负责人: GEUNYOUNG YOON
• 金额: $ 26.18万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-02 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6670855
• 关键词: biomedical equipment development; clinical biomedical equipment; clinical research; contact lens; cornea disorder; diagnosis design /evaluation; eye disorder diagnosis; human subject; human therapy evaluation; keratoconus; keratoplasty; optics; patient oriented research

DESCRIPTION (provided by applicant): Wavefront aberrations in the eye's optics degrade vision. These aberrations, including many higher order aberrations that are not corrected by conventional spectacles, are especially severe in patients with keratoconus and in patients who have had penetrating keratoplasty. Accurate measurement and correction of these higher order aberrations could result in substantial improvements in vision. However, little wave aberration data can be obtained from patients with these conditions, primarily because existing wavefront sensors have too small a dynamic range to measure the large aberrations in these eyes. Moreover, even if measurements were available, there are few available therapeutic alternatives. The research objectives of this bioengineering research project are to develop a robust wavefront sensor, with a large dynamic range, that will reliably diagnose the wave aberrations in highly aberrated eyes, and to develop a customized contact lens that can compensate for most of these aberrations. The key to expanding the dynamic range of the wavefront sensor is the use of a translational plate that increases spacing between wavefront sensing spots. The key to developing the contact lens is the use of high-power laser ablation of the contact lens based on the measurements with the wavefront sensor.

描述（由申请人提供）： 眼睛光学系统中的波前像差会降低视力。这些像差，包括许多不能用传统眼镜矫正的高阶像差，在圆锥角膜患者和穿透性角膜移植患者中尤其严重。准确测量和校正这些高阶像差可以导致视力的实质性改善。然而，从具有这些条件的患者中可以获得很少的波像差数据，主要是因为现有的波前传感器具有太小的动态范围以测量这些眼睛中的大像差。此外，即使测量是可用的，有几个可用的治疗替代品。该生物工程研究项目的研究目标是开发一种具有大动态范围的强大波前传感器，该传感器将可靠地诊断高度像差眼睛中的波像差，并开发一种可以补偿大部分这些像差的定制接触透镜。扩展波前传感器的动态范围的关键是使用增加波前感测点之间的间隔的平移板。开发接触透镜的关键是使用基于波前传感器测量的接触透镜的高功率激光烧蚀。